Related Experiment Video

Updated: Apr 23, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

38.4K

Systemic treatment with fumaric acid esters in six paediatric patients with psoriasis in a psoriasis centre

Kirsten Steinz1, Sascha Gerdes, Silja Domm

  • 1Psoriasis Centre at the Department of Dermatology, University Medical Centre Schleswig-Holstein, Campus Kiel, Kiel, Germany.

Dermatology (Basel, Switzerland)
|September 24, 2014
PubMed

Insights

Fumaric acid esters (FAE) offer a safe and effective systemic treatment for pediatric psoriasis, with significant improvements observed in skin condition and severity. This study highlights FAE as a valuable therapeutic option for children with this inflammatory skin disorder.

Area of Science:

  • Dermatology
  • Pediatric Medicine
  • Immunology

Background:

  • Psoriasis is a prevalent inflammatory skin condition with limited systemic treatment data in pediatric populations.
  • Psoriasis significantly impacts children's quality of life, necessitating effective therapeutic options.

Purpose of the Study:

  • To evaluate the safety and clinical efficacy of fumaric acid esters (FAE) in treating pediatric psoriasis.
  • To assess the impact of FAE on Psoriasis Area and Severity Index (PASI) and body surface area (BSA) in children.

Main Methods:

  • A cohort of six pediatric patients (ages 6-17) with psoriasis received FAE treatment.
  • Regular patient assessments were conducted, with efficacy measured by PASI and BSA scores.
  • Treatment duration averaged 17.8 months, with efficacy evaluated at 12 weeks.

Main Results:

  • All pediatric patients demonstrated improvement in their psoriasis.
  • Significant responses were observed, including PASI75 (2 patients), PASI90 (1 patient), and PASI100 (3 patients).
  • Adverse events included proteinuria in one patient and gastrointestinal discomfort in two; treatment was discontinued due to remission in two patients.

Conclusions:

  • Fumaric acid esters (FAE) represent a viable systemic treatment alternative for pediatric psoriasis.
  • FAE therapy shows promise for managing moderate to severe psoriasis in children, balancing efficacy with manageable side effects.
Abstract

More Related Videos

Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids13:05

Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids

Published on: June 28, 2019

8.0K
Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

1.1K

Related Concept Videos

Carboxylic Acids to Esters: Acid-Catalyzed (Fischer) Esterification Overview01:20

Carboxylic Acids to Esters: Acid-Catalyzed (Fischer) Esterification Overview

The Fischer esterification reaction was developed by the German chemist Emil Fischer in 1895. It is a condensation reaction between carboxylic acids and alcohols in an acidic medium to give esters and water.
15.1K
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
394
Carboxylic Acids to Esters: Acid-Catalyzed (Fischer) Esterification Mechanism01:13

Carboxylic Acids to Esters: Acid-Catalyzed (Fischer) Esterification Mechanism

Carboxylic acids react with alcohols to yield esters via an acid-catalyzed condensation reaction called Fischer esterification. This is a nucleophilic acyl substitution reaction that proceeds via a tetrahedral intermediate, where a water molecule is eliminated as the leaving group.
9.0K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
398
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
941
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
81