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Factors related to executive dysfunction after acute infarct
Ping Hua1, Xiao-ping Pan2, Rong Hu2
1Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Plos One
|September 24, 2014
Summary
Infarcts in the basal ganglia and corona radiata are linked to poor executive function after stroke. Male gender and lower NIHSS scores also predict worse outcomes on the MDRS I/P test.
Area of Science:
- Neurology
- Neuroscience
- Radiology
Background:
- Executive dysfunction is a common consequence of stroke.
- Identifying predictors of post-stroke executive dysfunction is crucial for patient management.
Purpose of the Study:
- To investigate the association between infarct location and executive dysfunction after acute infarction.
- To identify specific brain regions whose lesions correlate with impaired executive function.
Main Methods:
- 177 hospitalized patients with acute infarction were analyzed.
- Infarct location was determined using MRI (T2-W1 and FLAIR).
- Executive function was assessed using the Mattis Dementia Rating Scale Initiation/Perseveration (MDRS I/P) 7 days post-stroke.
Main Results:
- Patients with infarcts in the corona radiata or basal ganglia showed significantly lower MDRS I/P scores.
- The number of infarcts in the basal ganglia was significantly associated with lower MDRS I/P scores.
- Male gender and lower NIHSS scores were also associated with poorer executive function.
Conclusions:
- Infarct location in the basal ganglia and corona radiata are independent predictors of poor executive function post-stroke.
- Low NIHSS score and male gender are also significantly related to reduced executive function.
- These findings highlight the importance of infarct topography in predicting cognitive outcomes after stroke.
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