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Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

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Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Related Experiment Video

Updated: Apr 23, 2026

Displacement Analysis of Myocardial Mechanical Deformation DIAMOND Reveals Segmental Heterogeneity of Cardiac Function in Embryonic Zebrafish
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Diastolic function in anthracycline-treated children.

Ashraf Harahsheh1, Sanjeev Aggarwal2, Michael D Pettersen3

  • 11Department of Pediatrics,Division of Cardiology,Children's National Health System,The George Washington University School of Medicine,Washington,District of Columbia,United States of America.

Cardiology in the Young
|September 24, 2014
PubMed
Summary
This summary is machine-generated.

Pediatric cancer patients treated with anthracyclines showed normal diastolic function 5 years post-therapy, assessed by Doppler echocardiography. Long-term monitoring is recommended to detect potential future cardiac changes.

Keywords:
Cardiomyopathyechocardiogrampaediatric cardiologytissue Doppler imaging

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Area of Science:

  • Pediatric Cardiology
  • Cardiotoxicity
  • Cancer Therapeutics

Background:

  • Anthracyclines are vital childhood cancer drugs but pose a risk of cardiomyopathy.
  • Cardiac monitoring has primarily focused on systolic function, despite evidence of diastolic dysfunction in treated patients.

Purpose of the Study:

  • To evaluate diastolic function in children 5 years after anthracycline therapy.
  • Utilize transmitral inflow Doppler and tissue Doppler imaging for comprehensive diastolic assessment.

Main Methods:

  • Retrospective analysis of 63 anthracycline-treated pediatric patients.
  • Echocardiographic assessment included transmitral inflow (E, A, E/A, DT) and tissue Doppler (E', A', E/E', E'/A') parameters.

Main Results:

  • All measured indices of diastolic function were normal in the study cohort.
  • No significant diastolic dysfunction was detected 5 years post-anthracycline treatment.

Conclusions:

  • Diastolic function remains normal 5 years after anthracycline therapy in children, based on Doppler echocardiography.
  • Further longitudinal studies are necessary to ascertain the long-term evolution of diastolic function in this population.