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Demystifying NUT midline carcinoma: radiologic and pathologic correlations of an aggressive malignancy
Ryan J Bair1, Jeffrey F Chick, Nikunj R Chauhan
11 Department of Radiology, Division of Thoracic Imaging, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115.
Objective:
NUT midline carcinoma is a rare poorly differentiated aggressive subtype of squamous cell carcinoma. To date, fewer than 100 total cases have been reported.
Conclusion:
Given the rarity of this disease process and lack of pathognomonic imaging findings, a definitive diagnosis based solely on imaging findings alone is untenable. Select cases are used to emphasize the particularly infiltrative and aggressive nature of NUT midline carcinoma, which shows a complete disregard for normal tissue boundaries and rapid progression during brief intervals.