Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

Cardiopulmonary Resuscitation IV: Pharmacological Management

1.6K
Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
1.6K
Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

2.2K
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
2.2K
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

522
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
522
Acute Kidney Injury VI: Nursing Management01:22

Acute Kidney Injury VI: Nursing Management

778
Acute Kidney Injury (AKI) results in an inability to maintain fluid, electrolyte, and acid-base balance. Effective nursing management is critical in improving patient outcomes and includes comprehensive patient assessment and targeted interventions.Comprehensive Patient AssessmentA detailed history collection is essential, focusing on any recent infections, nephrotoxic medication use, or chronic conditions such as hypertension and diabetes that may contribute to AKI. During the physical...
778
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

408
Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
408
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

514
IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
514

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Closing the loop: Understanding ostomy reversal rates and risks in trauma patients.

The journal of trauma and acute care surgery·2026
Same author

Role of thromboelastography in risk stratifying patients with traumatic brain injury on prehospital antiplatelet agents.

Trauma surgery & acute care open·2026
Same author

Postdischarge outcomes of nonoperative management in complicated diverticulitis: Solution or Band-Aid?

Surgery·2026
Same author

Expanding Procedural Metrics: Rib Fixation as an Additional Surrogate of Trauma Center Performance.

Journal of the American College of Surgeons·2026
Same author

A nationwide comparison of intracranial pressure monitoring devices in pediatric severe traumatic brain injury: Impact on surgical intervention and mortality.

The journal of trauma and acute care surgery·2026
Same author

Geriatric trauma coagulation profiles: Impact of sex on clot formation.

The journal of trauma and acute care surgery·2026

Related Experiment Video

Updated: Apr 23, 2026

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
16:31

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

Published on: June 6, 2011

27.7K

Crystalloid administration during trauma resuscitation: does less really equal more?

John P Sharpe1, Louis J Magnotti, Martin A Croce

  • 1From the Department of Surgery, University of Tennessee Health Science Center, Memphis, Tennessee.

The Journal of Trauma and Acute Care Surgery
|September 24, 2014
PubMed
Summary

This study found that the ratio of crystalloid to packed red blood cells (C/PRBC) in initial trauma resuscitation did not impact pulmonary morbidity or mortality. Injury severity, not fluid ratio, was the primary driver of outcomes in trauma patients.

More Related Videos

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

33.8K
A Saline/Bipolar Radiofrequency Energy Device As an Adjunct for Hemostasis in Solid Organ Injury/Trauma
04:20

A Saline/Bipolar Radiofrequency Energy Device As an Adjunct for Hemostasis in Solid Organ Injury/Trauma

Published on: July 28, 2020

4.6K

Related Experiment Videos

Last Updated: Apr 23, 2026

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
16:31

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock

Published on: June 6, 2011

27.7K
A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

33.8K
A Saline/Bipolar Radiofrequency Energy Device As an Adjunct for Hemostasis in Solid Organ Injury/Trauma
04:20

A Saline/Bipolar Radiofrequency Energy Device As an Adjunct for Hemostasis in Solid Organ Injury/Trauma

Published on: July 28, 2020

4.6K

Area of Science:

  • Trauma Resuscitation
  • Critical Care Medicine
  • Emergency Medicine

Background:

  • Current trauma resuscitation strategies emphasize minimizing crystalloid and early blood product transfusion.
  • While high crystalloid volumes are linked to adverse outcomes, its role in initial resuscitation is debated.
  • The impact of crystalloid-to-packed red blood cell (C/PRBC) ratio during initial resuscitation on outcomes needs clarification.

Purpose of the Study:

  • To investigate the association between the C/PRBC ratio during emergency department resuscitation and pulmonary morbidity and mortality.
  • To determine if crystalloid limitation in initial trauma resuscitation affects patient outcomes.

Main Methods:

  • Prospective data collection over 6.5 years at a Level 1 trauma center.
  • Analysis of patients receiving >1 unit of PRBCs in the resuscitation room.
  • Stratification into high (>0.75) and low (<0.75) C/PRBC ratio groups.
  • Adjusted odds ratios calculated for ARDS, 24-hour mortality, and in-hospital mortality.

Main Results:

  • 383 patients analyzed; 192 in high-ratio and 191 in low-ratio groups.
  • Injury Severity Score (ISS), admission base excess, and time in resuscitation room were associated with mortality.
  • ISS was the only significant predictor of ARDS.
  • No significant association found between C/PRBC ratio and ARDS, 24-hour mortality, or in-hospital mortality.

Conclusions:

  • Injury severity, not the C/PRBC ratio, was the primary factor associated with pulmonary morbidity and mortality in this cohort.
  • The study did not observe the purported benefit of crystalloid limitation during initial trauma resuscitation.