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Related Experiment Videos

Dextrofenfluramine, but not 8-OH-DPAT affects the decrease in food consumed by rats submitted to physical exercise.

F Chaouloff1, J Danguir, J L Elghozi

  • 1Laboratorie de Pharmacologie, INSERM U7, Paris, France.

Pharmacology, Biochemistry, and Behavior
|February 1, 1989
PubMed
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Moderate exercise reduces food intake in rats during specific post-exercise periods. This effect may involve changes in the central serotonergic system, influencing feeding behavior.

Area of Science:

  • Neuroscience
  • Behavioral Science
  • Physiology

Background:

  • Physical exercise is known to influence various physiological processes, including appetite regulation.
  • Previous research suggests a link between exercise and increased central serotonin (5-HT) synthesis.
  • The impact of exercise on nocturnal feeding patterns and the role of the serotonergic system require further elucidation.

Purpose of the Study:

  • To investigate the effects of treadmill running on nocturnal food consumption in trained rats.
  • To examine the role of the central serotonergic system in mediating exercise-induced changes in feeding behavior.
  • To assess the impact of specific serotonin receptor agonists and antagonists on food intake following exercise.

Main Methods:

  • Trained rats underwent 1 hour of treadmill running.

Related Experiment Videos

  • Food intake was measured during different post-exercise periods.
  • Rats were treated with dextrofenfluramine (d-FEN), a 5-HT releaser and uptake inhibitor, or 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a 5-HT1A receptor agonist.
  • The anorexigenic and hyperphagic effects of these compounds were evaluated in exercised and control rats.

    • Main Results:

    • Exercise led to reduced food consumption in the late post-exercise period, with no significant changes in the initial 4 hours.
    • Dextrofenfluramine (d-FEN) administration promoted hypophagia (reduced appetite) in both groups, with a more pronounced effect in exercised rats.
    • The 5-HT1A receptor agonist 8-OH-DPAT did not alter food intake in either control or exercised rats at the tested doses.

    Conclusions:

    • Moderate physical exercise can induce a late-onset reduction in nocturnal food intake.
    • The serotonergic system, particularly through mechanisms influenced by d-FEN, appears to play a role in mediating the effects of exercise on feeding behavior.
    • 8-OH-DPAT, when administered at the onset of the dark cycle, does not stimulate appetite in rats, suggesting its limited role in initiating feeding behavior under these conditions.