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Hey bHLH transcription factors
David Weber1, Cornelia Wiese1, Manfred Gessler2
1Developmental Biochemistry, Theodor-Boveri-Institute/Biocenter, Wuerzburg University, Wuerzburg, Germany.
Current Topics in Developmental Biology
|September 25, 2014
Summary
Hey bHLH transcription factors regulate gene expression by repressing target genes. This review explores their interaction partners and target genes, detailing their roles in development and disease.
Area of Science:
- Molecular Biology
- Developmental Biology
- Genetics
Background:
- Hey bHLH transcription factors are downstream targets of Notch signaling.
- They function as transcriptional repressors, closely related to Hes proteins.
Purpose of the Study:
- To review interaction partners and target genes of Hey proteins.
- To present a model for Hey target gene regulation.
- To discuss the role of Hey proteins in cell fate and differentiation.
Main Methods:
- Review of existing literature on Hey proteins.
- Analysis of data from candidate gene approaches and systematic screens.
- Integration of findings to propose a regulatory model.
Main Results:
- Identification of numerous Hey target genes, often encoding other transcription factors.
- Hey proteins repress genes by promoter binding or inhibiting activators.
- Expression of Hey proteins influences cardiovascular, skeletal, neural development, and oncogenesis.
Conclusions:
- Hey proteins play crucial roles in developmental processes and disease.
- Understanding Hey protein function is key to explaining developmental defects and phenotypes in knockout models.
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