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Characterization of spontaneous malignant lymphomas in Japanese macaques (Macaca fuscata)
A Hirata1, K Hashimoto2, Y Katoh2
1Division of Animal Experiment, Life Science Research Center, Gifu University, Gifu City, Gifu, Japan akatsuki@gifu-u.ac.jp.
Veterinary Pathology
|September 25, 2014
Summary
Malignant lymphoma in Japanese macaques is characterized as T-cell type, often associated with simian lymphocryptovirus 2. This study details 5 cases, highlighting immunophenotypes and viral presence in these nonhuman primates.
Area of Science:
- Veterinary Pathology
- Primate Oncology
- Virology
Background:
- Lymphomas are common in nonhuman primates but poorly understood in Japanese macaques.
- This study investigates spontaneous malignant lymphomas in Macaca fuscata.
Purpose of the Study:
- To characterize the immunophenotypes of lymphomas in Japanese macaques.
- To determine the presence and role of simian lymphocryptoviruses (SLcVs) in these lymphomas.
Main Methods:
- Histologic and immunohistochemical analyses of 5 lymphoma cases.
- In situ hybridization for Epstein-Barr virus-encoded small RNA (EBER).
- Polymerase chain reaction and sequencing for M. fuscata lymphocryptovirus 2 detection.
Main Results:
- All 5 lymphomas were non-Hodgkin type with a T-cell phenotype (CD3+, CD20-, CD79α-).
- Lymphomas were classified into peripheral T-cell lymphoma, T-cell prolymphocytic leukemia, and unclassifiable T-cell lymphoma.
- M. fuscata lymphocryptovirus 2 was detected in EBER-positive cases.
Conclusions:
- T-cell lymphoma is more prevalent than B-cell lymphoma in Japanese macaques.
- M. fuscata lymphocryptovirus 2 is present in a subset of Japanese macaque lymphomas.
- Further research is needed to understand the oncogenic role of SLcVs in primate lymphomas.
