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Second trimester amniotic fluid retinol in patients developing preeclampsia
A Fruscalzo1, A P Londero, J Biasizzo
1Clinic of Obstetrics and Gynecology, DISM, AOU, "SM della Misericordia'" of Udine, P.le SM della Misericordia 15, 33100, Udine, Italy, fruscal@libero.it.
Background:
Retinol (ROH) is an essential micronutrient required for normal fetal development and an essential molecule for antioxidant processes.
Objective:
To investigate the putative role of ROH as a marker of preeclampsia in early second trimester amniotic fluid (AF).
Materials And Methods:
Case-control study comparing the concentration of ROH and other antioxidants such as uric acid, vitamin E and malondialdehyde (MDA) in second trimester AF in patients that later developed preeclampsia with normal pregnancies.
Results:
The concentration of ROH in amniotic fluids of women that later developed preeclampsia was significantly higher than those of uncomplicated pregnancies (66.72 µg/l (49.00-70.56) vs. 44.4 µg/l (31.9-51.17), p < 0.05). No statistical significant difference was found in uric acid, vitamin E and MDA concentration. In the multivariate logistic regression, concentrations of ROH in amniotic fluids directly correlate with the risk of developing preeclampsia (OR 1.13, IC 0.01-1.26, p < 0.05).
Conclusions:
Second trimester AF ROH concentration was significantly higher in pregnancies that developed preeclampsia compared to normal pregnancies.
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