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Second trimester amniotic fluid retinol in patients developing preeclampsia
A Fruscalzo1, A P Londero, J Biasizzo
1Clinic of Obstetrics and Gynecology, DISM, AOU, "SM della Misericordia'" of Udine, P.le SM della Misericordia 15, 33100, Udine, Italy, fruscal@libero.it.
Archives of Gynecology and Obstetrics
|September 25, 2014
Summary
Elevated retinol (ROH) levels in second-trimester amniotic fluid may indicate a higher risk of developing preeclampsia. This finding suggests ROH could serve as an early marker for this pregnancy complication.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Nutritional Biochemistry
Background:
- Retinol (ROH) is vital for fetal development and antioxidant functions.
- Preeclampsia is a serious pregnancy complication with significant maternal and fetal risks.
- Early identification of preeclampsia risk factors is crucial for timely intervention.
Purpose of the Study:
- To evaluate retinol (ROH) in amniotic fluid (AF) as a potential early marker for preeclampsia.
- To compare ROH concentrations in early second-trimester AF between women who develop preeclampsia and those with normal pregnancies.
Main Methods:
- A case-control study design was employed.
- Second-trimester amniotic fluid (AF) was analyzed for retinol (ROH), uric acid, vitamin E, and malondialdehyde (MDA).
- Participants were categorized into those who later developed preeclampsia and those with uncomplicated pregnancies.
Main Results:
- Significantly higher concentrations of retinol (ROH) were found in the amniotic fluid of women who later developed preeclampsia compared to normal pregnancies.
- No significant differences were observed in uric acid, vitamin E, or malondialdehyde (MDA) levels.
- Retinol (ROH) concentration in amniotic fluid showed a direct correlation with the risk of developing preeclampsia (OR 1.13).
Conclusions:
- Second-trimester amniotic fluid retinol (ROH) concentration is significantly elevated in pregnancies complicated by preeclampsia.
- Retinol (ROH) in amniotic fluid shows potential as an early predictive marker for preeclampsia.
- Further research is warranted to confirm the clinical utility of AF ROH in preeclampsia screening.
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