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Autism Spectrum Disorder

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.

Neural Regulation

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.

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Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

Low endogenous neural noise in autism.

Greg Davis¹, Kate Plaisted-Grant²

¹University of Cambridge, UK gjd1000@cam.ac.uk kcp1000@cam.ac.uk.

Autism : the International Journal of Research and Practice

|September 25, 2014

Summary

Autism spectrum disorder symptoms may stem from reduced neural noise, not excessive noise. This lower noise may enhance sensory detection but impair broader cognitive functions in autism research.

Keywords:

autism endogenous noise hyperphasic locus coeruleus neural networks stochastic resonance

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Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

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Published on: October 17, 2025

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Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells NPCs

Published on: March 2, 2018

Area of Science:

Neuroscience
Autism Spectrum Disorder Research
Computational Psychiatry

Background:

Heuristic theories propose single mechanisms for autism spectrum disorder (ASD).
A recent theory suggests 'noisy' neuronal signaling explains ASD deficits and superiorities via stochastic resonance.
This challenges the prevailing view of noise in neural systems.

Purpose of the Study:

To examine the role of neural noise in autism spectrum disorder.
To propose that reduced neural noise, rather than excess, underlies ASD characteristics.
To explore the functional consequences of neural noise levels in ASD.

Main Methods:

Discussion of three distinct mechanisms of noise in neural networks.
Analysis of how varying noise levels impact neural processing.
Theoretical modeling of noise's effect on sensory detection and discrimination.

Main Results:

Evidence suggests that autism spectrum disorder symptoms are associated with *less* neural noise, contrary to some theories.
Reduced neural noise may improve sensory detection and discrimination abilities in individuals with ASD.
This reduction in noise comes at the cost of other cognitive functions that benefit from neural noise.

Conclusions:

Autism spectrum disorder may be characterized by reduced neural noise, potentially linked to atypical brainstem activation.
This reduced noise enhances specific sensory processing but compromises widespread neural network benefits.
Future research should investigate the precise role and impact of neural noise levels in ASD.