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Updated: Apr 23, 2026

Isolation of Neonatal Extrahepatic Cholangiocytes
Published on: June 5, 2014
[A neonate with acute liver failure caused by herpes simplex infection]
Tessa Pols1, Jaco G van den Hoek, Richard A van Lingen
1Amalia kindercentrum, afd. Neonatologie, Zwolle.
Background:
(HSV) infection in neonates is rare. This infection is generally considered when there is a history of contact with a person who has a cold sore or when the mother has active genital herpes.
Case Description:
A 7-day-old female was admitted to hospital on suspicion of sepsis. Aciclovir was considered, but ultimately not given due to low suspicion of herpes infection. Her clinical situation deteriorated within a couple of days. Due to the advanced liver damage, the disease had a fulminant course and the patient died.
Conclusion:
Even without evidence of contact with HSV in the history, it is important to start acyclovir early in neonates with fever of unknown origin. A rare clinical presentation is acute liver failure. HSV infection can run a serious course in neonates; therefore, aciclovir should be started immediately if there is any suspicion.
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