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Updated: Apr 23, 2026
A Murine Tail Lymphedema Model
Published on: February 10, 2021
Tissue-engineered lymphatic graft for the treatment of lymphedema
Muholan Kanapathy1, Nikhil M Patel1, Deepak M Kalaskar1
1Division of Surgery & Interventional Science, UCL Centre for Nanotechnology & Regenerative Medicine, University College London, London, United Kingdom.
Background:
Lymphedema is a chronic debilitating condition and curative treatment is yet to be found. Tissue engineering approach, which combines cellular components, scaffold, and molecular signals hold great potential in the treatment of secondary lymphedema with the advent of lymphatic graft to reconstruct damaged collecting lymphatic vessel. This review highlights the ideal characteristics of lymphatic graft, the limitation and challenges faced, and the approaches in developing tissue-engineered lymphatic graft.
Methods:
Literature on tissue engineering of lymphatic system and lymphatic tissue biology was reviewed.
Results:
The prime challenge in the design and manufacturing of this graft is producing endothelialized conduit with intraluminal valves. Suitable scaffold material is needed to ensure stability and functionality of the construct. Endothelialization of the construct can be enhanced via biofunctionalization and nanotopography, which mimics extracellular matrix. Nanocomposite polymers with improved performance over existing biomaterials are likely to benefit the development of lymphatic graft.
Conclusions:
With the in-depth understanding of tissue engineering, nanotechnology, and improved knowledge on the biology of lymphatic regeneration, the aspiration to develop successful lymphatic graft is well achievable.
