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Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich...
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Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
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Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
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Updated: Apr 23, 2026

Author Spotlight: Advancing Cell Membrane Biophysics - Exploring Interactions and Challenges Through Experimental and Computational Approaches
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Triptan partition in model membranes.

Irene Wood1, Mónica Pickholz

  • 1Departamento de Tecnología Farmacéutica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, Buenos Aires, CP1113, Argentina.

Journal of Molecular Modeling
|September 25, 2014
PubMed
Summary

Molecular dynamics simulations reveal how sumatriptan and naratriptan interact with lipid bilayers. These triptans primarily reside in the water and lipid head-water interphase, avoiding the hydrophobic core.

Area of Science:

  • Computational Biophysics
  • Membrane Biophysics
  • Pharmacology

Background:

  • Triptans, such as sumatriptan and naratriptan, are widely used for migraine treatment.
  • Understanding their interaction with biological membranes is crucial for drug delivery and efficacy.
  • Previous studies lack detailed insights into triptan partitioning within model membrane systems.

Purpose of the Study:

  • To investigate the molecular behavior and partitioning of protonated sumatriptan and naratriptan within a hydrated POPC lipid bilayer.
  • To elucidate the specific interactions stabilizing triptans at the lipid-water interphase.
  • To determine the influence of drug concentration on triptan membrane accessibility.

Main Methods:

  • Molecular dynamics (MD) simulations were employed to model protonated triptans in a POPC bilayer.

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  • Simulations were conducted at two distinct drug concentrations.
  • Analysis focused on triptan localization, interactions (hydrogen bonds, salt bridges, cation-π), and accessibility to membrane regions.

    • Main Results:

    • Both sumatriptan and naratriptan partitioned between the lipid head-water interphase and the bulk water phase.
    • Increased drug concentration led to greater access to the water phase.
    • Triptans were stabilized at the interphase via specific interactions, with no penetration into the hydrophobic bilayer core observed.

    Conclusions:

    • Protonated triptans exhibit preferential localization at the lipid-water interphase and water phase, influenced by concentration.
    • Specific molecular interactions govern triptan stabilization within the model membrane system.
    • Naratriptan displayed a slightly higher affinity for the water phase, potentially due to its structural characteristics.