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Combined impact of negative lifestyle factors on cardiovascular risk in children: a randomized prospective study
Ursina Meyer1, Christian Schindler2, Tamara Bloesch3
1Centre on Aging and Mobility, University of Zürich, Zürich, Switzerland; Department of Human Movement Science, Maastricht University, Maastricht, The Netherlands; Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland.
Insights
Accumulating negative lifestyle factors in children significantly increases cardiovascular risk (CVR) over four years. Early assessment of these factors in clinical practice can aid in childhood CVR prevention.
Area of Science:
- Pediatric Health
- Cardiovascular Risk Assessment
- Lifestyle Medicine
Background:
- Negative lifestyle factors are linked to increased cardiovascular risk (CVR) in children.
- Research on the combined impact of these factors in a general pediatric population is limited.
Purpose of the Study:
- To quantify the combined impact of easily assessable negative lifestyle factors on CVR scores in children over a 4-year period.
- To investigate the association between the number of negative lifestyle factors and CVR in a general pediatric population.
Main Methods:
- A cohort of 502 children (aged 6-13) underwent baseline health assessments, with 64% followed up after 4 years.
- Lifestyle factors assessed included overweight, physical inactivity, high media use, low outdoor time, skipping breakfast, and parental smoking/inactivity/overweight.
- Cardiovascular risk (CVR) score at follow-up was based on waist circumference, blood pressure, glucose, HDL, and triglycerides.
Main Results:
- Children with five or more negative lifestyle factors had a 63.5% probability of being in the highest CVR score tertile after 4 years.
- The probability of high CVR scores increased progressively with the number of negative lifestyle factors, from 15.4% for one factor to 63.5% for five or more.
- These associations remained significant after adjusting for age, sex, pubertal stage, and social class.
Conclusions:
- An accumulation of negative lifestyle factors in childhood is associated with elevated CVR scores within 4 years.
- These lifestyle factors are readily identifiable in clinical settings, enabling early detection and prevention strategies for childhood CVR.
Purpose:
Negative lifestyle factors are known to be associated with increased cardiovascular risk (CVR) in children, but research on their combined impact on a general population of children is sparse. Therefore, we aimed to quantify the combined impact of easily assessable negative lifestyle factors on the CVR scores of randomly selected children after 4 years.
Methods:
Of the 540 randomly selected 6- to 13-year-old children, 502 children participated in a baseline health assessment, and 64% were assessed again after 4 years. Measures included anthropometry, fasting blood samples, and a health assessment questionnaire. Participants scored one point for each negative lifestyle factor at baseline: overweight; physical inactivity; high media consumption; little outdoor time; skipping breakfast; and having a parent who has ever smoked, is inactive, or overweight. A CVR score at follow-up was constructed by averaging sex- and age-related z-scores of waist circumference, blood pressure, glucose, inverted high-density lipoprotein, and triglycerides.
Results:
The age-, sex-, pubertal stage-, and social class-adjusted probabilities (95% confidence interval) for being in the highest CVR score tertile at follow-up for children who had at most one (n = 48), two (n = 64), three (n = 56), four (n = 41), or five or more (n = 14) risky lifestyle factors were 15.4% (8.9-25.3), 24.3% (17.4-32.8), 36.0% (28.6-44.2), 49.8% (38.6-61.0), and 63.5% (47.2-77.2), respectively.
Conclusions:
Even in childhood, an accumulation of negative lifestyle factors is associated with higher CVR scores after 4 years. These negative lifestyle factors are easy to assess in clinical practice and allow early detection and prevention of CVR in childhood.
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