Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychological Responses to Stress01:20

Psychological Responses to Stress

973
Psychological responses to stress encompass the various cognitive and emotional reactions individuals experience when faced with challenging or threatening situations, such as a job loss. Prolonged exposure to stressors can disturb emotional balance, increasing negative emotions (e.g., anxiety and sadness) and diminishing positive emotions (e.g., joy and satisfaction). These persistent emotional shifts are associated with an increased risk of both physical illness and mental health issues, such...
973
Stress Concentrations01:13

Stress Concentrations

809
The concept of stress concentration is crucial for understanding how materials respond under bending stresses, particularly when there are irregularities or discontinuities in the material's geometry. Normally, stress in a symmetric member subjected to pure bending is assumed to be uniformly distributed across the entire cross-section. However, this assumption does not hold when there are variations in the cross-sectional geometry or the presence of notches and holes.
The stress...
809
Stress Concentrations01:24

Stress Concentrations

830
Stress concentration is when stress intensifies near discontinuities such as holes or abrupt cross-sectional changes in a structural member. This localized stress can often surpass the average stress within the member. The stress distribution in flat bars, either with a circular hole or varying widths connected by fillets, can be determined experimentally using a photoelastic method. The results are based on ratios of geometric parameters like the ratio of the hole's radius to the smaller...
830
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

48.6K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
48.6K
Introduction to Stress and Lifestyle01:27

Introduction to Stress and Lifestyle

849
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
849
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

751
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
751

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Plasma oxytocin, early predictor of transient postoperative arginine vasopressin deficiency.

The Journal of clinical endocrinology and metabolism·2026
Same author

Diagnostic Value of Neurofilament Light Chain and Glial Fibrillary Acidic Protein in Differentiating Primary From Serious Secondary Headache.

European journal of neurology·2026
Same author

Neurofilament light chain and glial fibrillary acidic protein as potential early indicators of osmotic brain stress in hyponatremia and its correction.

European journal of endocrinology·2026
Same author

Low-positive CMV IgG serostatus before allogeneic hematopoietic cell transplantation is not associated with increased CMV reactivation risk.

Bone marrow transplantation·2026
Same author

Recognition and accreditation of postgraduate training centres in endocrinology in Europe.

Endocrine connections·2026
Same author

Oxytocin substitution therapy in patients with AVP deficiency (central diabetes insipidus): study protocol of a double-blind, randomised placebo-controlled trial.

BMJ open·2026

Related Experiment Video

Updated: Apr 23, 2026

The Trier Social Stress Test Protocol for Inducing Psychological Stress
09:39

The Trier Social Stress Test Protocol for Inducing Psychological Stress

Published on: October 19, 2011

56.9K

Copeptin concentrations during psychological stress: the PsyCo study.

Judith Siegenthaler1, Carla Walti1, Sandrine Andrea Urwyler1

  • 1Clinic of EndocrinologyDiabetology, and Metabolism, University Hospital Basel, Petersgraben 4, Basel CH-4031, SwitzerlandDepartment of Internal MedicineKantonsspital Aarau, Tellstrasse, Aaraun CH-5001, Switzerland.

European Journal of Endocrinology
|September 25, 2014
PubMed
Summary

Copeptin levels, a marker of physical stress, increase with psychological stress in healthy individuals. This response is diminished in patients with central diabetes insipidus (DI).

More Related Videos

Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm
07:26

Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm

Published on: May 4, 2020

3.0K
Measuring Biophysical and Psychological Stress Levels Following Visitation to Three Locations with Differing Levels of Nature
05:33

Measuring Biophysical and Psychological Stress Levels Following Visitation to Three Locations with Differing Levels of Nature

Published on: June 19, 2019

8.0K

Related Experiment Videos

Last Updated: Apr 23, 2026

The Trier Social Stress Test Protocol for Inducing Psychological Stress
09:39

The Trier Social Stress Test Protocol for Inducing Psychological Stress

Published on: October 19, 2011

56.9K
Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm
07:26

Assessment of Stress Effects on Cognitive Flexibility using an Operant Strategy Shifting Paradigm

Published on: May 4, 2020

3.0K
Measuring Biophysical and Psychological Stress Levels Following Visitation to Three Locations with Differing Levels of Nature
05:33

Measuring Biophysical and Psychological Stress Levels Following Visitation to Three Locations with Differing Levels of Nature

Published on: June 19, 2019

8.0K

Area of Science:

  • Endocrinology
  • Neuroscience
  • Psychosomatic Medicine

Background:

  • Copeptin, a surrogate biomarker for arginine vasopressin, is established as an indicator of physical stress.
  • The impact of psychological stress on copeptin secretion remains largely unexplored.
  • Understanding this relationship is crucial for a comprehensive view of stress biomarkers.

Purpose of the Study:

  • To investigate the effect of acute psychological stress on copeptin levels in healthy volunteers.
  • To compare the copeptin response to psychological stress in healthy individuals versus patients with central diabetes insipidus (DI).

Main Methods:

  • A prospective observational study utilizing the Trier Social Stress Test (TSST).
  • Participants included 20 healthy adults and 8 patients with central DI.
  • Serum copeptin and cortisol concentrations were measured at multiple time points during and after the TSST, alongside self-reported stress levels.

Main Results:

  • Healthy volunteers exhibited a significant increase in copeptin levels following the TSST, peaking immediately post-test.
  • Feelings of tension and avoidance were identified as significant predictors of copeptin elevation.
  • Patients with central DI demonstrated lower baseline copeptin levels and a blunted response to psychological stress compared to healthy controls.

Conclusions:

  • Psychological stress significantly elevates copeptin levels in healthy individuals.
  • The stress-induced increase in copeptin is attenuated in patients with central diabetes insipidus.
  • These findings suggest copeptin's utility in reflecting psychological stress responses, with potential implications for understanding stress-related disorders.