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Updated: Apr 23, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
Crystal structure of 4-methyl-sulfanyl-2-phenyl-quinazoline
Mohammed B Alshammari1, Keith Smith2, Amany S Hegazy2
1Chemistry Department, College of Sciences and Humanities, Salman bin Abdulaziz University, PO Box 83, Al-Kharij 11942, Saudi Arabia.
Abstract:
In the title compound, C15H12N2S, the methylthioquinazoline group is planar with the methyl C displaced by only 0.116 (3) Å from the plane of the quinazoline moiety. The dihedral angle between the phenyl ring and the quinazoline ring system is 13.95 (5)°. In the crystal, each molecule is linked by π-π stacking between to two adjacent inversion-related molecules. On one side, the inverted quinazoline groups interact with a centroid-centroid distance of 3.7105 (9) Å. On the other side, the quinazoline group interacts with the pyrimidine and phenyl rings of the second neighbour with centroid-centroid distances of 3.5287 (8) and 3.8601 (9) Å, respectively.
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