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Related Concept Videos

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Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
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Delayed convergence between brain network structure and function in rolandic epilepsy.

René M H Besseling1, Jacobus F A Jansen2, Geke M Overvliet3

  • 1Epilepsy Center Kempenhaeghe Heeze, Netherlands ; Research School for Mental Health and Neuroscience, Maastricht University Maastricht, Netherlands ; Department of Radiology, Maastricht University Medical Center Maastricht, Netherlands.

Frontiers in Human Neuroscience
|September 25, 2014
PubMed
Summary
This summary is machine-generated.

Children with Rolandic epilepsy (RE) show reduced brain structure-function synergy, indicating a developmental delay in network maturation. This is most apparent in younger children and affects specific brain networks crucial for language.

Keywords:
brain maturationfunctional connectivitygraph theoryrolandic epilepsystructural connectivitystructure-function correlation

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Pediatric Neurology

Background:

  • Rolandic epilepsy (RE) is associated with language impairments and occurs during critical brain development periods.
  • Previous studies noted concordant abnormalities in structural connectivity (SC) and functional connectivity (FC) in RE.
  • Understanding the synergy between SC and FC is crucial, as they mutually influence each other.

Purpose of the Study:

  • To investigate abnormalities in the synergy between structural and functional connectivity (SC-FC synergy) in children with Rolandic epilepsy.
  • To explore how SC-FC synergy changes with age in RE patients compared to healthy controls.

Main Methods:

  • Utilized 3T MRI (structural, diffusion-weighted, resting-state functional) on 22 children with RE and 22 healthy controls.
  • Assessed SC using constrained spherical deconvolution tractography and FC using time series correlation.
  • Analyzed SC-FC correlation across sparsity values and performed graph analysis on SC and FC networks separately.

Main Results:

  • Significantly reduced SC-FC correlation was observed in children with RE compared to controls, particularly in younger participants.
  • The most pronounced effects were found in left/right centro-temporal and medial parietal networks.
  • Graph analysis did not reveal significant abnormalities in individual SC or FC network organization.

Conclusions:

  • Reduced SC-FC correlation in RE suggests impaired synergy between brain structure and function, potentially indicating delayed network maturation.
  • The findings highlight RE as a possible developmental disorder affecting brain network maturation.
  • Medial parietal connections, linking centro-temporal networks and relevant for language, are particularly implicated.