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The Association between 25-Hydroxyvitamin D and Hemoglobin A1c Levels in Patients with Type 2 Diabetes and Stage 1-5

Farshad Kajbaf1, Romuald Mentaverri2, Momar Diouf3

  • 1Department of Endocrinology and Nutrition, University Hospital of Amiens, 80054 Amiens, France ; INSERM Unit 1088, Jules Verne University of Picardie, 80037 Amiens, France.

International Journal of Endocrinology
|September 25, 2014
PubMed

Insights

Higher vitamin D levels are linked to better blood sugar control in diabetic patients with chronic kidney disease (CKD). This study found a significant negative correlation between 25-hydroxyvitamin D (25(OH)D) and hemoglobin A1c (HbA1c) levels.

Area of Science:

  • Endocrinology
  • Nephrology
  • Nutritional Science

Background:

  • Diabetes mellitus and chronic kidney disease (CKD) are significant global health concerns.
  • Vitamin D deficiency is prevalent in CKD patients and may impact glycemic control.
  • Hemoglobin A1c (HbA1c) is a key marker for long-term glycemic control.

Purpose of the Study:

  • To investigate the association between plasma 25-hydroxyvitamin D (25(OH)D) levels and blood HbA1c in diabetic patients across different CKD stages.
  • To determine if 25(OH)D levels independently correlate with HbA1c, considering potential confounders.

Main Methods:

  • Retrospective analysis of data from 2003-2012, including 245 diabetic patients with varying CKD severity.
  • Correlation analysis between 25(OH)D and HbA1c, stratified by CKD stage and vitamin D status.
  • Multivariate linear regression to assess independent associations, adjusting for covariates like erythrocyte metformin levels.

Main Results:

  • A significant negative correlation was observed between 25(OH)D and HbA1c levels overall (r = -0.387, P < 0.0001) and within CKD subgroups.
  • Mean HbA1c levels increased progressively with decreasing vitamin D status: sufficiency (6.7±1.0%), insufficiency (7.3±1.5%), and deficiency (8.4±2.0%).
  • Multivariate analysis identified 25(OH)D level as the sole significant factor associated with HbA1c (P < 0.0001).

Conclusions:

  • Plasma 25(OH)D levels are negatively correlated with HbA1c levels in diabetic patients with CKD.
  • This association is independent of other study covariates, suggesting a direct relationship.
  • Maintaining adequate vitamin D status may be important for glycemic management in this patient population.

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