Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Disorders01:29

Bone Disorders

7.9K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
7.9K
Fractures: Bone Repair01:27

Fractures: Bone Repair

5.8K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
5.8K
Fatigue01:21

Fatigue

1.1K
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Postmenopausal women with normal BMD who have fractures have deteriorated bone microarchitecture: A prospective analysis from The OFELY study.

Bone·2024
Same author

Previous fracture and subsequent fracture risk: a meta-analysis to update FRAX.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2023
Same author

Update of the fracture risk prediction tool FRAX: a systematic review of potential cohorts and analysis plan.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2022
Same author

Klinefelter Bone Microarchitecture Evolution with Testosterone Replacement Therapy.

Calcified tissue international·2022
Same author

Influence of loading conditions in finite element analysis assessed by HR-pQCT on ex vivo fracture prediction.

Bone·2021
Same author

Cost-effectiveness of treatment of women aged 70 years and older with both osteopenia and microstructural deterioration.

Bone·2020

Related Experiment Video

Updated: Apr 23, 2026

Method and Instrumented Fixture for Femoral Fracture Testing in a Sideways Fall-on-the-Hip Position
06:58

Method and Instrumented Fixture for Femoral Fracture Testing in a Sideways Fall-on-the-Hip Position

Published on: August 17, 2017

9.1K

How to predict fragility fracture beyond 10 years? The OFELY study.

E Sornay-Rendu1, F Duboeuf, S Boutroy

  • 1INSERM Research Unité Mixte de Recherche 1033 and Université de Lyon, 69437 Lyon, France.

The Journal of Clinical Endocrinology and Metabolism
|September 25, 2014
PubMed
Summary

Low bone mineral density (BMD) significantly increases fracture risk over 20 years in women. Baseline BMD is a better long-term predictor of fractures than clinical risk factors alone.

More Related Videos

Imaging of the Microstructural Failure Mechanism in the Human Hip
08:43

Imaging of the Microstructural Failure Mechanism in the Human Hip

Published on: September 29, 2023

1.8K
Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
09:02

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population

Published on: January 31, 2025

1.7K

Related Experiment Videos

Last Updated: Apr 23, 2026

Method and Instrumented Fixture for Femoral Fracture Testing in a Sideways Fall-on-the-Hip Position
06:58

Method and Instrumented Fixture for Femoral Fracture Testing in a Sideways Fall-on-the-Hip Position

Published on: August 17, 2017

9.1K
Imaging of the Microstructural Failure Mechanism in the Human Hip
08:43

Imaging of the Microstructural Failure Mechanism in the Human Hip

Published on: September 29, 2023

1.8K
Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population
09:02

Cortical Bone Assessment Using Ultrasonic Guided Waves: A Reproducibility Study in a Healthy Population

Published on: January 31, 2025

1.7K

Area of Science:

  • Gerontology
  • Osteoporosis Research
  • Epidemiology

Background:

  • Low bone mineral density (BMD) is a key factor in fragility fractures (Fx).
  • Long-term prediction of fracture risk based on BMD is not well-documented.

Purpose of the Study:

  • To analyze the risk of incident fragility fractures (Fx) beyond 10 years in women.
  • To evaluate the predictive value of baseline BMD and clinical risk factors for very long-term Fx risk.

Main Methods:

  • Longitudinal cohort study (Os des Femmes de Lyon) of 867 women aged 40+ over 20 years.
  • Assessment of baseline BMD using dual-energy X-ray absorptiometry.
  • Analysis of clinical risk factors and the Fracture Risk Assessment Tool (FRAX).

Main Results:

  • 245 women sustained incident fragility Fx over 20 years.
  • Fractures occurring after 10 years (Fx 10-20) were associated with younger age, lower FRAX scores, greater grip strength, and higher BMD compared to Fx within the first 10 years (Fx 0-10).
  • Decreased BMD at multiple sites significantly increased Fx 10-20 risk; osteoporosis increased risk for both Fx 0-10 and Fx 10-20, while osteopenia did not significantly increase Fx risk beyond 10 years.

Conclusions:

  • Low BMD is a significant predictor of fracture risk in women over a 20-year period.
  • Baseline BMD provides superior long-term prediction of fracture risk compared to clinical risk factors alone, particularly beyond 10 years.