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Updated: Apr 23, 2026

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
Published on: August 9, 2024
How accurate are we in sending patients to angiography?
Marta Neves1, Pedro Ponce, Pedro Maia
1Coimbra Vascular Access Center, NephroCare Portugal, Coimbra, Portugal.
Insights
Routine physical examination and monitoring are crucial for hemodialysis patients. Specific referral criteria, like increased venous pressure and reduced flow, indicate significant lesions requiring intervention in arteriovenous fistulas.
Area of Science:
- Nephrology
- Vascular Surgery
- Interventional Radiology
Background:
- Vascular access (VA) is essential for hemodialysis.
- Surveillance and monitoring techniques are integral to VA care.
- Identifying referral criteria for endovascular intervention (EI) is important.
Purpose of the Study:
- To define referral criteria associated with the need for therapeutic endovascular intervention (EI) in hemodialysis vascular access (VA).
Main Methods:
- Retrospective study of 1265 VA procedures (AVFs and AVGs) over one year.
- Patients were categorized based on the presence or absence of significant lesions on angiography.
- Multivariate analysis identified factors associated with significant lesions.
Main Results:
- For AVFs, increased dynamic venous pressure, abnormal physical examination findings, reduced access flow, and low mean Kt/V (<1.4) were independently associated with significant lesions.
- In AVGs, while multivariate analysis showed no independent association, 97.2% of referred cases had clinically suspected relevant lesions.
Conclusions:
- Routine physical examination and monitoring are imperative for VA evaluation, particularly for AVFs.
- Specific clinical findings can predict the need for endovascular intervention in hemodialysis access.
- Effective surveillance strategies improve the management of hemodialysis vascular access.
Abstract:
Physical examination (PE), and surveillance and monitoring techniques should be a core part of standard care provided to hemodialysis patients. This study aimed to define which referral criteria within a vascular access (VA) program were associated with indication for therapeutic endovascular intervention (EI). Retrospective study at two vascular centers, considering 1265 procedures between 1 November 2012 and 30 November 2013. All 617 arteriovenous fistulas (AVFs) and 648 arteriovenous grafts (AVGs) referred for angiography were enrolled. Each population was divided into two groups regarding absence (group 1) or presence (group 2) of a significant lesion on the angiogram, contemplating formal indication for EI. On multivariate analysis, factors independently associated with presence of a significant lesion in AVFs were referral due to increased dynamic venous pressure (p = 0.01), suspected stenosis by abnormal PE (p = 0.019), confirmed reduction in access flow rate (p = 0.003), and mean Kt/V < 1.4 (p = 0.004). In AVGs, although multivariate analysis did not find independent association of studied factors with presence of significant stenoses, 97.2% of the exams revealed relevant lesions previously suspected clinically. Aside from surveillance strategies, monitoring strategies including routine PE of the VA are imperative as an integral part of evaluation, especially in AVFs.
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