Autosomal dominant polycystic kidney disease

Area of Science:

• Nephrology
• Genetics
• Internal Medicine

Background:

• Autosomal dominant polycystic kidney disease (ADPKD) is the most prevalent inherited kidney disease.
• The hallmark of ADPKD is the development of enlarging cysts within the kidneys.

Purpose of the Study:

• To outline the renal and extrarenal manifestations of ADPKD.
• To discuss current therapeutic strategies targeting ADPKD complications.
• To highlight the importance of early detection and management of associated conditions.

Main Methods:

• Review of clinical manifestations including renal and extrarenal symptoms.
• Discussion of management approaches for hypertension, pain, urinary tract infections, and nephrolithiasis.
• Consideration of hormonal therapy effects and screening for intracranial aneurysms.

Main Results:

• ADPKD presents with diverse renal issues like injury, infections, stones, and hematuria.
• Extrarenal complications include pain, hypertension, liver cysts, and increased risk of aneurysms.
• Management focuses on controlling symptoms and preventing complications due to irreversible disease progression.

Conclusions:

• Therapies for ADPKD are palliative, focusing on managing clinical manifestations.
• Early intervention for hypertension and prompt treatment of infections are crucial.
• Screening for complications like intracranial aneurysms and careful consideration of hormonal therapies are advised.