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Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Related Experiment Video

Updated: Apr 23, 2026

The Forced Swim Test as a Model of Depressive-like Behavior

The Forced Swim Test as a Model of Depressive-like Behavior

Published on: March 2, 2015

Depression embodied: an ambiguous striving against fading.

Louise Danielsson^1,2, Susanne Rosberg^1,2

¹Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Scandinavian Journal of Caring Sciences

|September 25, 2014

Summary

This study explores depression as an embodied experience, focusing on the lived body. Findings reveal an ambiguous struggle against fading, with implications for enhancing patient connection and well-being in clinical practice.

Keywords:

depression hermeneutics lived body lived experience person-centred care phenomenology

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Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Design and Implementation of an fMRI Study Examining Thought Suppression in Young Women with, and At-risk, for Depression

Published on: May 19, 2015

Area of Science:

Psychology
Phenomenology
Clinical Research

Background:

Depression is often linked to physical discomfort, yet the subjective experience of the body in depression is under-researched.
The concept of the 'lived body' offers a framework for understanding depression as an embodied phenomenon.

Purpose of the Study:

To explore depression as an embodied experience using a hermeneutic phenomenological approach.
To identify thematic structures and dimensions of the embodied process in depression.

Main Methods:

Conducted narrative-based interviews with 11 adults diagnosed with depression.
Employed a hermeneutic phenomenological analysis to interpret the interview data.

Main Results:

Identified a core thematic structure of an ambiguous striving against fading.
Disclosed five subthemes representing disabling (feeling estranged, confined, burdensome) and enabling (sensing life, seeking belongingness) dimensions.

Conclusions:

Depression is an embodied phenomenon characterized by an ambiguous struggle.
Clinical practice can benefit from enhancing enabling embodied dimensions and acknowledging the complexity of the patient's struggle.