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Current and potential applications of bismuth-based drugs
Donal M Keogan1, Darren M Griffith2
1Centre for Synthesis & Chemical Biology, Department of Pharmaceutical & Medicinal Chemistry, Royal College of Surgeons in Ireland, 123 St. Stephens Green, Dublin 2, Ireland.
Molecules (Basel, Switzerland)
|September 25, 2014
Summary
Bismuth compounds offer broad therapeutic potential beyond gastrointestinal treatments. This review highlights their antimicrobial, anti-leishmanial, and anti-cancer properties, encouraging further research into bismuth-based medicines.
Area of Science:
- Medicinal Chemistry
- Pharmacology
- Biochemistry
Background:
- Bismuth compounds have a long history of medicinal use, particularly for gastrointestinal disorders.
- Beyond gastroprotection and H. pylori treatment, bismuth exhibits diverse biological activities.
Purpose of the Study:
- To review current bismuth-based drugs and their applications.
- To explore emerging medicinal uses of bismuth compounds.
- To discuss the biological chemistry and molecular targets of bismuth.
Main Methods:
- Literature review of recent developments in bismuth-based drug research.
- Analysis of biological chemistry and biomolecular targets of bismuth.
Main Results:
- Bismuth compounds demonstrate efficacy against H. pylori and possess gastroprotective effects.
- Bismuth exhibits significant antimicrobial, anti-leishmanial, and anti-cancer properties.
- Key biomolecular targets for bismuth therapies are identified.
Conclusions:
- Bismuth-based drugs have established and potential therapeutic applications.
- Further research into bismuth's biological chemistry can unlock new medicinal uses.
- This review aims to stimulate novel contributions to bismuth-based medicine.
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