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Updated: Apr 23, 2026
Fluorescent Nanoparticles for the Measurement of Ion Concentration in Biological Systems
Published on: July 4, 2011
Supported core-shell nanobiosensors for quantitative fluorescence imaging of extracellular pH
Jérémie Asselin1, Carl Roy, Denis Boudreau
1Département de chimie, Faculté de Sciences et Génie, Université Laval, Québec (QC), Canada G1V 0A6. denis.boudreau@chm.ulaval.ca.
Abstract:
Covalent "click" cycloaddition was used to functionalize silica substrates with pH-sensitive nanoparticles, thus producing uniform and highly luminescent analytical devices usable in both commercial fluorimeters and fluorescence microscopes. Quantitative and spatially-resolved extracellular pH measurements were successfully achieved on live cardiac fibroblasts with these novel ion-sensitive surfaces.
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