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Detection and molecular characterization of human cosavirus in a pediatric patient with acute gastroenteritis, Japan

Shoko Okitsu1, Pattara Khamrin2, Aksara Thongprachum3

  • 1Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan; Department of Developmental Medical Sciences, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
|September 25, 2014
PubMed

Insights

Human cosavirus (HCoSV) was detected in a child with gastroenteritis in Japan, suggesting it as a potential cause of illness. This finding highlights the importance of monitoring HCoSV in pediatric diarrhea cases.

Area of Science:

  • Virology
  • Gastroenterology
  • Public Health

Background:

  • Human cosavirus (HCoSV) is a recently identified genus within the Picornaviridae family, with unclear pathogenicity.
  • Picornaviridae family includes significant human pathogens, necessitating further research into related viruses like HCoSV.

Purpose of the Study:

  • To identify and characterize Human cosavirus (HCoSV) in a pediatric patient with acute gastroenteritis in Japan.
  • To investigate the potential role of HCoSV as a causal agent in pediatric diarrhea.

Main Methods:

  • Detection of HCoSV in a stool sample from a child with acute gastroenteritis.
  • Phylogenetic and sequence analyses to classify the identified HCoSV strain.
  • Exclusion of co-infection with common diarrhea-causing viruses.

Main Results:

  • An HCoSV strain (10928/2012/JPN) was detected in 0.16% of stool samples analyzed.
  • The identified strain represents a new genotype within the HCoSV A species.
  • This marks the first detection of HCoSV in a clinical specimen from Japan.

Conclusions:

  • HCoSV may act as a causal pathogen in pediatric acute gastroenteritis.
  • Surveillance for HCoSV is crucial for identifying viral agents in children with diarrhea, even with low detection rates.

Keywords:
ChildDiarrheaGenotypeHuman cosavirusJapan

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