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Updated: Apr 23, 2026

ECM Protein Nanofibers and Nanostructures Engineered Using Surface-initiated Assembly
Published on: April 17, 2014
Esterase-activated release of naproxen from supramolecular nanofibres
Martin Conda-Sheridan1, Sungsoo S Lee, Adam T Preslar
1Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, IL 60611, USA. s-stupp@northwestern.edu.
Abstract:
Nanofibre forming peptide amphiphiles were conjugated to naproxen through an esterase-sensitive linker. The amount of naproxen released, in the presence of enzymes, was influenced by the linker conjugating the drug to the supramolecular assembly. In vitro studies showed the anti-inflammatory activity of the released drug was maintained.
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