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Updated: Apr 23, 2026

Lineage Tracing and Clonal Analysis in Developing Cerebral Cortex Using Mosaic Analysis with Double Markers MADM

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Lineage sorting in apes.

Thomas Mailund¹, Kasper Munch, Mikkel Heide Schierup

¹Bioinformatics Research Centre, Aarhus University, DK-8000 Aarhus C, Denmark; email: mailund@birc.au.dk , kaspermunch@birc.au.dk , mheide@birc.au.dk.

Annual Review of Genetics

|September 25, 2014

Summary

This summary is machine-generated.

Genomic recombination creates varied histories within species. Analyzing lineage sorting in great apes reveals ancestral population sizes, selection, and recombination rates.

Keywords:

great apes evolution incomplete lineage sorting phylogenetics population genomics speciation

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Area of Science:

Genomics
Evolutionary Biology
Population Genetics

Background:

Recombination leads to diverse genealogical histories across a genome.
Speciation involves lineage sorting, where genetic lineages distribute into descendant species.
Incomplete lineage sorting can occur if speciation events are closely spaced, causing gene genealogies to mismatch species phylogeny.

Purpose of the Study:

To review and present recent methodologies for modeling genomic lineage sorting.
To demonstrate the application of these models for inferring ancestral population characteristics.
To investigate population sizes, natural selection, and recombination rates in ancestral species.

Main Methods:

Review of recent computational and statistical approaches for modeling lineage sorting.
Application of lineage sorting models to genome-wide alignments of great ape species.
Comparative genomic analysis to infer evolutionary parameters.

Main Results:

Models effectively capture the variation in lineage sorting across the genome.
Analysis of great ape genomes provides insights into ancestral population dynamics.
Inferred parameters include ancestral population sizes, recombination rates, and evidence of natural selection.

Conclusions:

Genomic lineage sorting is a powerful tool for reconstructing evolutionary history.
The studied models enable robust inference of past demographic and selective processes.
Great ape genome data, analyzed through lineage sorting models, illuminates their evolutionary past.