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[Age-related decrease of 11C-N-methylspiperone in vivo binding to human striatum detected by PET].

M Iyo, T Yamasaki, H Fukuda

    Kaku Igaku. the Japanese Journal of Nuclear Medicine
    |February 1, 1989
    PubMed
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    Aging reduces dopamine D2 receptor activity in the human striatum. Positron emission tomography revealed a decrease in 11C-N-methylspiperone binding with age, indicating lower dopaminergic function.

    Area of Science:

    • Neuroscience
    • Radiochemistry
    • Gerontology

    Background:

    • Dopamine D2 receptors in the striatum are crucial for motor control and reward.
    • Age-related changes in neurotransmitter systems are not fully understood.
    • 11C-N-methylspiperone is a radiotracer used to study dopamine receptor binding.

    Purpose of the Study:

    • To investigate the effect of aging on dopamine D2 receptor binding in the human striatum.
    • To quantify the relationship between age and dopaminergic activity.

    Main Methods:

    • Positron emission tomography (PET) was used to image 11C-N-methylspiperone binding in 11 healthy volunteers (aged 22-72).
    • Striatal and cerebellar uptake of the radiotracer was measured over time.
    • The association rate constant (k3) was calculated using the cerebellum as an input function.

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    Main Results:

    • 11C-N-methylspiperone uptake was highest in the striatum and gradually increased.
    • Cerebellar uptake peaked early and then declined rapidly.
    • An exponential decrease in the k3 value was observed with increasing age, from 0.035/min in a 22-year-old to 0.020/min in a 72-year-old.

    Conclusions:

    • Dopaminergic activity through D2 dopamine receptors significantly reduces with aging in the human striatum.
    • These findings have implications for understanding age-related neurological changes and potential therapeutic targets.