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Correlation between structure/function and optic disc microcirculation in myopic glaucoma, measured with laser

Naoko Aizawa, Hiroshi Kunikata, Yukihiro Shiga

  • 1Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. ntoru@oph.med.tohoku.ac.jp.

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Summary
This summary is machine-generated.

Laser speckle flowgraphy (LSFG) measures mean blur rate (MBR) to identify glaucoma in myopic eyes. LSFG-MBR and cpRNFLT independently indicate glaucoma presence and severity.

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Glaucoma Research

Background:

  • Glaucoma diagnosis is challenging in myopic eyes due to variable optic disc appearance.
  • Accurate glaucoma identification in myopia is clinically significant.

Purpose of the Study:

  • To evaluate the efficacy of laser speckle flowgraphy (LSFG) in measuring optic disc microcirculation (mean blur rate - MBR).
  • To assess the ability of LSFG-MBR to identify glaucoma and classify its severity in eyes with myopic optic discs.

Main Methods:

  • 129 eyes (21 normal disc, 108 myopic disc) were analyzed.
  • Glaucoma severity was assessed using standard automated perimetry (SAP) and optical coherence tomography (OCT) for circumpapillary retinal nerve fiber layer thickness (cpRNFLT).
  • Optic nerve head (ONH) MBR was measured using LSFG.

Main Results:

  • ONH MBR and cpRNFLT significantly decreased with increasing glaucoma severity.
  • MBR showed significant correlations with cpRNFLT (r=0.65) and mean deviation (MD) (r=0.63).
  • MBR and cpRNFLT were identified as independent predictors of glaucoma presence and severity via regression analyses. MBR demonstrated high diagnostic accuracy (AUC=0.86).

Conclusions:

  • LSFG measurement of MBR is a non-invasive, objective method for glaucoma detection in myopic eyes.
  • MBR, alongside cpRNFLT, aids in identifying glaucoma and grading its severity in myopic optic discs.