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Related Concept Videos

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Related Experiment Video

Updated: Apr 23, 2026

Highly Sensitive and Quantitative Detection of Proteins and Their Isoforms by Capillary Isoelectric Focusing Method
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PIP-DB: the Protein Isoelectric Point database.

Egle Bunkute1, Christopher Cummins1, Fraser J Crofts1

  • 1School of Life and Health Sciences and School of Engineering and Applied Science, University of Aston, Aston Triangle, Birmingham B4 7ET, UK.

Bioinformatics (Oxford, England)
|September 26, 2014
PubMed
Summary
This summary is machine-generated.

The Protein Isoelectric Point database (PIP-DB) centralizes protein pI data for researchers. This accessible web application allows searching and comparison of protein isoelectric point values.

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Area of Science:

  • Biochemistry
  • Bioinformatics
  • Proteomics

Background:

  • The isoelectric point (pI) is a fundamental protein property, representing the pH at which a protein has no net charge.
  • Literature data on protein pI values is extensive but fragmented.
  • A centralized resource is needed for efficient data retrieval and analysis.

Purpose of the Study:

  • To create a comprehensive, publicly accessible database of protein isoelectric point (pI) values.
  • To develop a user-friendly web application for querying and utilizing this data.
  • To provide a resource for protein research, comparison, and benchmarking.

Main Methods:

  • Collected and collated existing literature data on protein isoelectric points.
  • Developed a web-enabled SQL database (PIP-DB) to store the curated data.
  • Implemented an HTML GUI front-end for public access and searching.

Main Results:

  • Established the Protein Isoelectric Point database (PIP-DB).
  • PIP-DB is a web-accessible SQL database with a searchable HTML interface.
  • The database allows searching across various protein properties.

Conclusions:

  • PIP-DB provides a valuable, centralized resource for protein isoelectric point data.
  • The web application facilitates easy access and utilization of pI information for researchers.
  • This resource supports protein research, comparison, and benchmarking efforts.