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[Long-term experiences with lyophilized soft dura (Lyodura S) as a connective tissue substitute in pediatric surgery]
1Kinderkrankenhaus Park Schönfeld, Chirurgische Abteilung, Kassel.
Insights
This study used plastic closures with softened dura mater in 45 children for various conditions. The procedure showed no infections or rejections, with good scar results, despite an 11% mortality rate.
Area of Science:
- Pediatric Surgery
- Biomaterials Science
- Regenerative Medicine
Context:
- The study addresses reconstructive challenges in pediatric congenital anomalies.
- Utilizes lyophilized softened dura mater as a biological implant material.
- Examines surgical outcomes in a cohort of 45 children.
Purpose:
- To evaluate the efficacy and safety of plastic closures with lyophilized softened dura mater in pediatric reconstructive surgery.
- To assess complication rates, including infection and rejection.
- To analyze functional and cosmetic outcomes of the surgical repair.
Summary:
- A total of 45 pediatric patients underwent surgical repair using plastic closures with lyophilized softened dura mater between 1979 and 1985.
- Indications included gastroschisis, omphaloceles, meningomyeloceles, meningoceles, diaphragmatic aplasia, and esophageal atresia with tracheoesophageal fistula.
- No instances of implant infection or rejection were reported. The overall mortality rate was 11%, with complications and causes of death detailed.
- Postoperative follow-up at semi-annual intervals indicated good functional and cosmetic results for the scars.
Impact:
- Demonstrates the potential of dura mater grafts in pediatric reconstructive surgery.
- Highlights the low complication rate regarding implant viability.
- Provides long-term outcome data for complex congenital defect repairs.
Abstract:
Between 1979 and 1985 plastic closures with lyophilised softened dura mater were performed in 45 children with the following indications: gastrochisis: 8; omphaloceles: 2; meningomyeloceles: 29; meningoceles: 3; diaphragmatic aplasia: 1; oesophageal atresia with tracheo-oesophageal fistula: 2. Infection as well as rejection of the implants were never observed. Mortality came up to 11%. Complications and causes of death are described. A follow-up was carried out postoperatively at semi-annual intervals. The scars showed good functional and cosmetic results.