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Updated: Apr 23, 2026
Sublingual Immunotherapy as an Alternative to Induce Protection Against Acute Respiratory Infections
Published on: August 30, 2014
Pidotimod may prevent recurrent respiratory infections in children
A Licari1, M De Amici, S Nigrisoli
1Immuno‑Pneumo‑Allergy Unit Department of Pediatrics, University of Pavia, Fondazione IRCCS San Matteo, Pavia, Italy - gl.marseglia@smatteo.pv.it.
Aim:
Recurrent respiratory infections (RRI) constitute a social problem for both the pharmaco-economic impact and the burden for the family. Pidotimod is a synthetic immunostimulant. The aim of this study was to evaluate the effects of pidotimod on RRI prevention in children.
Methods:
Globally, 100 children (49 males, mean age 4.7 ± 1.2 years) with RRI were enrolled in the study. At baseline, children were randomly assigned to the treatment with pidotimod 400 mg/die or not for two months. Children were visited at baseline, after 30 (T1) and 60 (T2) days, and at follow-up (120 days; T3). Number of children with upper and lower airways symptoms, medications use, school attendance, and paediatric visits for RRI were evaluated.
Results:
Pidotimod treatment was able of significantly reducing the number of children with upper and lower airways symptoms, and medications use, increasing school attendance, and reducing pediatric visits for RRI.
Conclusion:
This study provided the evidence that pidotimod may be able of preventing RRI in children.
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