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Effect of nicorandil on coronary spasm
T Aizawa1, K Ogasawara, F Nakamura
1Cardiovascular Institute Hospital, Tokyo, Japan.
The American Journal of Cardiology
|June 20, 1989
Summary
Nicorandil effectively relieved coronary spasms in patients with angina pectoris. This antianginal drug demonstrated prompt and complete spasmolytic effects, offering a beneficial treatment option for coronary spasm.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Dynamic coronary obstruction is a key factor in angina pectoris pathogenesis.
- Antianginal drugs primarily act by dilating coronary arteries and relieving coronary spasm.
Observation:
- This study assessed the acute vasodilating effects of nicorandil, a novel antianginal medication.
- The study included 10 patients experiencing spontaneous and ergonovine-induced coronary spasms.
Findings:
- Nicorandil provided prompt and complete relief of both spontaneous and evoked coronary spasms in all participants.
- The drug exhibited significant coronary spasmolytic activity.
Implications:
- Nicorandil's demonstrated efficacy suggests it is a beneficial therapeutic agent for managing coronary spasm.
- These findings support the use of nicorandil in patients where coronary spasm is the primary cause of angina.