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Coronary vasodilatory action after nicorandil: a quantitative angiographic study
1Thoraxcenter, University Hospital Rotterdam, The Netherlands.
The American Journal of Cardiology
|June 20, 1989
Summary
Nicorandil effectively dilates major coronary arteries, including stenotic segments, in patients. This study shows nicorandil
Area of Science:
- Cardiology
- Pharmacology
Background:
- Coronary artery disease necessitates effective vasodilators.
- Nicorandil is a potassium channel activator with vasodilatory properties.
Purpose of the Study:
- To investigate the vasodilatory effects of nicorandil on major coronary arteries.
- To assess nicorandil's impact on both normal and stenotic coronary segments.
Main Methods:
- Sublingual administration of nicorandil (20 mg and 40 mg) to 22 patients.
- Quantitative analysis of coronary angiograms using a computer-assisted system.
- Measurement of coronary artery diameter changes in various segments.
Main Results:
- Nicorandil significantly increased the diameter of normal coronary artery segments (left anterior descending and circumflex arteries).
- Significant vasodilation was observed in most stenotic coronary segments.
- Systemic blood pressure decreased, but heart rate remained unaffected.
Conclusions:
- Nicorandil induces significant epicardial coronary vasodilation in normal and most stenotic segments.
- The sublingual route and tested doses of nicorandil are effective for coronary vasodilation.
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