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Acute generalized exanthematous pustulosis induced by ceftriaxone use
Hikmet Tekin Nacaroglu1, Mehmet Celegen1, Gülcihan Ozek2
1Department of Pediatric Allergy, Dr Behcet Uz Children's Hospital, Izmir, Turkey. Head of Department: Demet Can Assoc. Prof., MD.
Postepy Dermatologii I Alergologii
|September 26, 2014
Summary
Acute generalized exanthematous pustulosis (AGEP) is a rare drug-induced rash. This case report details the first pediatric instance of AGEP caused by ceftriaxone in a sickle cell anemia patient.
Area of Science:
- Dermatology
- Pharmacology
- Pediatrics
Background:
- Acute generalized exanthematous pustulosis (AGEP) is a rare adverse drug reaction.
- It typically presents with fever and a generalized pustular rash.
- Drug use is implicated in 90% of AGEP cases.
Observation:
- A 15-year-old male with sickle cell anemia developed AGEP.
- The patient received ceftriaxone for a vaso-occlusive crisis.
- Within three days, widespread erythematous pustular lesions and fever appeared.
Findings:
- Discontinuation of ceftriaxone led to symptom resolution.
- A patch test confirmed sensitivity to ceftriaxone.
- Clinical and histopathological findings supported the AGEP diagnosis.
Implications:
- This is the first reported pediatric case of AGEP induced by ceftriaxone.
- Highlights the importance of considering ceftriaxone as a potential cause of AGEP in pediatric patients.
- Emphasizes the need for vigilant monitoring of adverse drug reactions in patients with underlying conditions like sickle cell anemia.
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