Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

1.2K
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
1.2K
Depression: Overview01:18

Depression: Overview

1.1K
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
1.1K
Long-term Depression01:05

Long-term Depression

27.2K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
27.2K
Long-term Depression01:03

Long-term Depression

2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.6K
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

872
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
872
Menopause01:28

Menopause

5.0K
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of outcomes, costs, and feasibility of home-based geriatric rehabilitation after inpatient rehabilitation: study protocol of the "Better@Home" multicentre prospective cohort study with historical control group.

BMC geriatrics·2025
Same author

Chronic PPI use after anti-reflux surgery: a retrospective observational pilot study.

BMC gastroenterology·2025
Same author

[COVID in a 'psychiatric nursing home'].

Tijdschrift voor psychiatrie·2024
Same author

[Value-based healthcare in mental health care: a practical example].

Tijdschrift voor psychiatrie·2024
Same author

Risk of Four Geriatric Syndromes: A Comparison of Mental Health Care and General Hospital Inpatients.

The Journal of frailty & aging·2023
Same author

[Psychiatric symptoms and COVID-19: results of a national case register].

Tijdschrift voor psychiatrie·2022

Related Experiment Video

Updated: Apr 23, 2026

Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design
07:40

Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design

Published on: May 31, 2021

3.2K

Depression in later life: a more somatic presentation?

J M Hegeman1, M W M de Waal2, H C Comijs3

  • 1Department of Psychiatry, St. Antoniusziekenhuis, Utrecht, The Netherlands; Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.

Journal of Affective Disorders
|September 26, 2014
PubMed
Summary
This summary is machine-generated.

Late-life depression may present with fewer mood and motivation symptoms in older individuals (≥70 years). Chronic somatic diseases and age do not worsen somatic symptoms in late-life depression.

Keywords:
AgeDepressionSomatic disease burden

More Related Videos

A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

21.5K
An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

22.3K

Related Experiment Videos

Last Updated: Apr 23, 2026

Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design
07:40

Validation of a Psychosocial Intervention on Body Image in Older People: An Experimental Design

Published on: May 31, 2021

3.2K
A New Method for Inducing a Depression-Like Behavior in Rats
07:57

A New Method for Inducing a Depression-Like Behavior in Rats

Published on: February 22, 2018

21.5K
An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

22.3K

Area of Science:

  • Gerontology
  • Psychiatry
  • Epidemiology

Background:

  • Late-life depression can manifest with more physical symptoms than early-life depression.
  • Chronic somatic diseases and advanced age may influence symptom presentation in older adults.

Purpose of the Study:

  • To examine how chronic somatic diseases and increasing age affect symptom dimensions in late-life depression.
  • To investigate the relationship between somatic disease burden, age, and specific depression symptom clusters in older adults.

Main Methods:

  • Utilized baseline data from 429 older adults (aged 60-93) in the Netherlands Study of Depression in Old Age.
  • Assessed symptom dimensions using mood, somatic, and motivation subscales of the Inventory of Depressive Symptomatology-Self Report (IDS-SR).
  • Employed linear regression to analyze the effects of chronic somatic diseases and age on IDS-SR subscale scores.

Main Results:

  • In depressed older individuals, a higher somatic disease burden correlated with increased mood symptoms (B = 2.02, p = 0.001).
  • Increasing age was associated with decreased mood (B = -2.30, p < 0.001) and motivation (B = -1.01, p = 0.006) symptom scores.
  • No significant difference in the association between somatic disease burden and somatic symptoms was found between depressed and non-depressed groups.

Conclusions:

  • Neither increased somatic disease burden nor advanced age appears to exacerbate somatic symptoms in late-life depression.
  • Late-life depression in individuals aged 70 and older may be underrecognized due to potentially fewer mood and motivational symptoms compared to younger older adults.
  • The IDS-SR subscales are specific to older age, limiting comparisons with earlier life depression.