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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

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Analysis of the structural diversity, substitution patterns, and frequency of nitrogen heterocycles among U.S. FDA

Edon Vitaku1, David T Smith, Jon T Njardarson

  • 1Department of Chemistry and Biochemistry, 1306 E. University Boulevard, University of Arizona , Tucson, Arizona 85721, United States.

Journal of Medicinal Chemistry
|September 26, 2014
PubMed

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