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Effects of anti-TNF-α agents on circulating endothelial-derived and platelet-derived microparticles in psoriasis

Fabien Pelletier1, Francine Garnache-Ottou, Sabeha Biichlé

  • 1University of Franche-Comté, INSERM UMR1098, Besançon, France; Dermatology Department, Besançon Hospital, Besançon, France; Hematology or Immunology Laboratory, EFS- Bourgogne Franche-Comté, UMR1098, Biomonitoring, Besançon, France.

Experimental Dermatology
|September 27, 2014
PubMed

Insights

Tumor necrosis factor-alpha (TNF-α) blockers significantly reduced circulating microparticles in severe psoriasis patients, improving clinical outcomes. This suggests TNF blockade may lower cardiovascular risk by decreasing endothelial dysfunction markers.

Area of Science:

  • Immunodermatology
  • Cardiovascular Risk Assessment
  • Biomarker Discovery

Background:

  • Psoriasis pathogenesis involves Tumor Necrosis Factor-alpha (TNF-α) secretion, leading to microparticle release into circulation.
  • Elevated microparticle levels, including circulating endothelial cells, are associated with endothelial dysfunction and are observed in psoriasis patients.

Discussion:

  • Anti-TNF-α therapy in severe psoriasis patients led to significant reductions in platelet and endothelial microparticles.
  • Clinical improvement, measured by PASI score reduction, correlated with decreased microparticle counts in patients treated with anti-TNF-α agents.

Key Insights:

  • Successful anti-TNF-α treatment in psoriasis is linked to a significant decrease in circulating microparticles.
  • Microparticle levels serve as indicators of endothelial dysfunction and are elevated in psoriatic disease.

Outlook:

  • TNF blockade demonstrates potential in mitigating cardiovascular risk by reducing circulating microparticles.
  • Further research could explore anti-TNF-α agents as a strategy to improve endothelial function and cardiovascular health in psoriasis.
Keywords:
anti-TNF-α agentsendothelial microparticlesplatelet microparticlespsoriasis

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