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Dosage Regimen: Individualization01:24

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Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
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Impression Management Techniques IV: Altercasting01:14

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Altercasting is a strategic communication technique in which an individual imposes a specific identity or social role onto another person to influence their behavior and shape the interaction. By presuming a role—such as “responsible leader” or “patient person”—altercasting encourages the target to conform to that identity, often aligning their behavior with the expectations associated with the role. The power of this tactic lies in its subtlety; once a role...
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The Stereotype Content Model (SCM) was first proposed by Susan Fiske and her colleagues (Fiske, Cuddy, Glick & Xu, 2002; see also Fiske, 2012 and Fiske, 2017). The SCM specifies that when someone encounters a new group, they will stereotype them based on two metrics: warmth—or that group’s perceived intent, and how likely they are to provide help or inflict harm—and competence—or their ability to carry out that objective. Depending on the warmth-competence...
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Role-based identities are central to understanding how individuals navigate social environments by adopting distinct self-conceptions aligned with various societal roles. These identities are not fixed traits but are constructed through personal actions and the social feedback individuals receive in context-specific interactions. Each social role, such as student, teacher, or friend, carries a set of expectations and norms that influence how people think, feel, and behave within that...
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Impression Management Techniques III: Aligning Actions01:29

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Aligning actions are communicative strategies individuals employ to maintain social harmony and preserve personal identity in the face of potential disruptions to social norms. These actions are particularly important in managing social impressions when one's behavior might be seen as inappropriate, incompetent, or morally questionable.Types of Aligning ActionsThe three principal types of aligning actions are disclaimers, accounts, and apologies.DisclaimersDisclaimers are preventive; they are...
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Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
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PRRT: Defining the paradigm shift to achieve standardization and individualization.

Lisa Bodei1, Mark Kidd2, Richard P Baum3

  • 1Division of Nuclear Medicine, European Institute of Oncology, Milan, Italy Department of Gastroenterological Surgery, Yale University School of Medicine, New Haven, Connecticut; and lisa.bodei@ieo.it.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
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PubMed
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Standardizing peptide receptor radionuclide therapy is crucial for treating neuroendocrine tumors. This approach enables personalized treatment strategies and facilitates regulatory approval for improved patient outcomes.

Keywords:
PRRTindividualizationstandardization

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiotherapy

Background:

  • Peptide receptor radionuclide therapy (PRRT) is a key treatment for advanced neuroendocrine tumors.
  • Standardization of PRRT is essential for clinical trial design and regulatory approval.
  • Current PRRT approaches lack standardization, hindering treatment optimization.

Purpose of the Study:

  • To highlight the necessity of standardizing PRRT for neuroendocrine tumors.
  • To emphasize the role of standardization in developing personalized treatment paradigms.
  • To explore factors influencing PRRT efficacy and toxicity.

Main Methods:

  • Review of current PRRT practices and challenges.
  • Discussion on the importance of dosimetry for treatment optimization.
  • Exploration of patient- and tumor-specific factors influencing outcomes.

Main Results:

  • Standardization is critical for defining response criteria like progression-free survival.
  • Homogeneous clinical trials (Phase II/III) require standardized protocols.
  • Personalized treatment requires optimization based on dosimetry and individual characteristics.

Conclusions:

  • Standardizing PRRT is the first step towards personalized treatment for neuroendocrine tumors.
  • Dosimetry and patient-specific factors are crucial for optimizing PRRT efficacy and minimizing toxicity.
  • Further research into genetic elements influencing treatment response is warranted.