Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Preparation and Reactions of Sulfides02:26

Preparation and Reactions of Sulfides

4.3K
Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
4.3K
Carboxylic Acids to Acid Chlorides01:18

Carboxylic Acids to Acid Chlorides

6.8K
Carboxylic acids react with SOCl2 or PCl5 to form acid chlorides. Amongst the carboxylic acid derivatives, acid chlorides are the most reactive and synthetically important derivatives. They are useful reagents for Friedel–Crafts acylation of some aromatic compounds.
6.8K
Hydration of Cement01:24

Hydration of Cement

1.8K
Hydration of cement is a chemical reaction between cement particles and water. This process occurs primarily through two mechanisms: through-solution and topochemical. In the through-solution process, anhydrous compounds dissolve into their constituents, hydrates form in the solution, and then precipitate from the supersaturated solution. The topochemical process involves solid-state reactions at the cement particle surface. The through-solution process dominates the topochemical process at the...
1.8K
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions01:20

Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions

1.9K
Arenediazonium substitution reactions occur when the diazonium group is substituted by various functional groups such as halides, hydroxyl, nitrile, etc. For instance, arenediazonium salts react with copper(I) salts of chloride, bromide, or cyanide to form corresponding aryl chlorides, bromides, and nitriles. These reactions are named Sandmeyer reactions. Although the mechanism of this reaction is complicated, as illustrated in Figure 1, they are believed to progress via an aryl copper...
1.9K
Synthesis and Decomposition Reactions02:17

Synthesis and Decomposition Reactions

31.2K
Synthesis and decomposition are two types of redox reactions. Synthesis means to make something, whereas decomposition means to break something. The reactions are accompanied by chemical and energy changes. 
31.2K
Dehydration Synthesis01:15

Dehydration Synthesis

133.3K
Overview
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.
Synthesis of carbohydrates
Sugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from...
133.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synthesis of the Phospha-Wittig Reagent Me<sub>3</sub>P = P(C<sub>2</sub>F<sub>5</sub>) and Generation of a Phospanyl-Wittig Derivative Me<sub>3</sub>P = C(CF<sub>3</sub>)P(C<sub>2</sub>F<sub>5</sub>)F.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Ki-67 shapes the nucleolus by anchoring chromatin via its amphiphilic properties.

The EMBO journal·2026
Same author

Stable Cyclic Peterson Olefination Intermediates.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Bis(trifluoromethyl)disulfide and the EtP<sub>4</sub> Phosphazene Base-Formation of a Bench-Stable [EtP<sub>4</sub>SCF<sub>3</sub>]<sup>+</sup>[SCF<sub>3</sub>]<sup>-</sup> Salt.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Bis(pentafluoroethyl)arsinous Acid and the Bis(pentafluoroethyl)arsinite─Synthesis, Structural Characterization and Transition-Metal Complexes.

Inorganic chemistry·2026
Same author

Tuning reactivity through implementation of the HSAB concept in oxygen- and sulphur-bridged Al/P and Ga/P FLPs.

Dalton transactions (Cambridge, England : 2003)·2026

Related Experiment Video

Updated: Apr 23, 2026

Fabrication and Optimization of Type II Silicon Clathrate Films
06:53

Fabrication and Optimization of Type II Silicon Clathrate Films

Published on: October 14, 2025

1.2K

Synthesis of chlorosilicates.

Simon Steinhauer1, Tobias Böttcher, Nico Schwarze

  • 1Universität Bielefeld, Fakultät für Chemie, Centrum für Molekulare Materialien, Universitätsstrasse 25, 33615 Bielefeld (Germany).

Angewandte Chemie (International Ed. in English)
|September 27, 2014
PubMed
Summary

Chlorosilicates are key intermediates in chlorosilane reactions. Introducing electron-withdrawing groups stabilizes these compounds, enabling the isolation and structural analysis of novel (pentafluoroethyl)chlorosilicate salts.

Keywords:
Lewis acidselectron-withdrawing groupsnucleophilic substitutionsilicatessolvent effects

More Related Videos

Preparation of Functional Silica Using a Bioinspired Method
08:04

Preparation of Functional Silica Using a Bioinspired Method

Published on: August 1, 2018

18.4K
Synthesis of Zeolites Using the ADOR Assembly-Disassembly-Organization-Reassembly Route
08:26

Synthesis of Zeolites Using the ADOR Assembly-Disassembly-Organization-Reassembly Route

Published on: April 3, 2016

15.3K

Related Experiment Videos

Last Updated: Apr 23, 2026

Fabrication and Optimization of Type II Silicon Clathrate Films
06:53

Fabrication and Optimization of Type II Silicon Clathrate Films

Published on: October 14, 2025

1.2K
Preparation of Functional Silica Using a Bioinspired Method
08:04

Preparation of Functional Silica Using a Bioinspired Method

Published on: August 1, 2018

18.4K
Synthesis of Zeolites Using the ADOR Assembly-Disassembly-Organization-Reassembly Route
08:26

Synthesis of Zeolites Using the ADOR Assembly-Disassembly-Organization-Reassembly Route

Published on: April 3, 2016

15.3K

Area of Science:

  • Organosilicon chemistry
  • Fluorine chemistry
  • Reaction mechanisms

Background:

  • Chlorosilicates are reactive intermediates in nucleophilic substitution (SN2) reactions involving chlorosilanes.
  • Stabilization of these intermediates is crucial for their isolation and study.
  • Electron-withdrawing substituents are known to enhance the stability of chemical species.

Purpose of the Study:

  • To investigate the stabilization of chlorosilicates using electron-withdrawing substituents.
  • To synthesize and structurally characterize novel chlorosilicate salts.
  • To explore the role of (pentafluoroethyl) groups in stabilizing chlorosilicate intermediates.

Main Methods:

  • Synthesis of chlorosilicate salts containing (pentafluoroethyl) substituents.
  • Isolation and purification of the target compounds.
  • Structural characterization using techniques such as X-ray crystallography.

Main Results:

  • Successful isolation of various (pentafluoroethyl)chlorosilicate salts.
  • Structural characterization confirmed the formation of stable chlorosilicate species.
  • The presence of pentafluoroethyl groups effectively stabilized the chlorosilicate intermediates.

Conclusions:

  • Chlorosilicates can be effectively stabilized by incorporating electron-withdrawing substituents like the pentafluoroethyl group.
  • The isolated and characterized salts provide valuable insights into the structure and reactivity of these important intermediates.
  • This work advances the understanding of SN2 reaction mechanisms involving chlorosilanes.