Related Experiment Video
Updated: Apr 23, 2026

Author Spotlight: Investigating Wound Healing in Mice Models of Oronasal Fistulas
Published on: September 8, 2023
Chronic Ulceration and Sinus Formation due to Foreign Body: An Often-Forgotten Problem
Karin Birgitte Hansen1, Finn Gottrup2
1Hvidovre University Hospital, Copenhagen, Denmark.
Abstract:
Foreign bodies like residues of suture or mesh may lead to a foreign body reaction, cavity formation and continuous secretion and perhaps ulceration. We present a more than 9 years long medical record of a 49 year old man after a simple surgical procedure. The background was a sinus formation generated from a foreign body reaction. The case report shows that this condition is often overlooked and even using advanced equipment, it is difficult to diagnose. The only solution is to diagnose and remove the triggering cause. Fistulography and ultrasound scanning seem to be the optimal diagnostic tool in these cases. The knowledge of the foreign body reaction in tissue continuously needs to be reestablished in the health care system especially in areas, where implantation of foreign material is used.
Insights
Foreign body reactions to surgical materials can cause persistent sinus formation and secretion. Early diagnosis and removal of the foreign body, often aided by fistulography and ultrasound, are crucial for resolution.
Area of Science:
- Medical Case Reports
- Surgical Complications
- Immunology
Background:
- Foreign bodies, such as suture or mesh remnants, can elicit a foreign body reaction.
- This reaction may manifest as sinus formation, cavity development, chronic secretion, and ulceration.
- Such complications can arise even after seemingly simple surgical procedures.
Observation:
- A case report details a 49-year-old male with a 9-year history of sinus formation stemming from a foreign body reaction.
- The condition was challenging to diagnose, even with advanced imaging techniques.
- Persistent secretion and sinus formation were the primary clinical manifestations.
Findings:
- Foreign body reactions are often overlooked causes of chronic post-surgical complications.
- Fistulography and ultrasound scanning are identified as optimal diagnostic tools for identifying the causative foreign body.
- Complete resolution was achieved by diagnosing and removing the inciting foreign material.
Implications:
- Re-establishing awareness of foreign body reactions within the healthcare system is essential.
- This is particularly important in fields utilizing implanted foreign materials.
- Prompt diagnosis and intervention can prevent prolonged morbidity associated with these reactions.
Related Concept Videos
Peptic Ulcer Disease II: Pathophysiology
Peptic Ulcer Disease II: Pathophysiology
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.
Peptic Ulcer Disease I: Introduction
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
Peptic Ulcer Disease I: Introduction
Chronic Bowel Disorders: Introduction
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Chronic Pharyngitis
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
