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Translating Extracellular Electron Transfer Activities with Organic Electrochemical Transistors

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Published on: January 31, 2025

Electronic transport via proteins.

Nadav Amdursky¹, Debora Marchak, Lior Sepunaru

¹Dept. of Materials & Interfaces, Weizmann Institute of Science, Rehovot, 76305, Israel.

Advanced Materials (Deerfield Beach, Fla.)

|September 27, 2014

Summary

This summary is machine-generated.

Proteins show promise as efficient electronic conductors for bioelectronic devices, outperforming saturated molecules but lagging behind conjugated ones. Their conduction mechanisms involve hopping and tunneling, influenced by cofactors.

Keywords:

bioelectronics electron transfer electron transport molecular electronics proteins

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Area of Science:

Molecular electronics
Bioelectronics
Biophysics

Background:

Proteins offer unique physical and chemical functions for molecular electronics.
Their potential as building components for bioelectronic devices is explored.
Proteins are efficient electronic conductors compared to saturated organic molecules.

Purpose of the Study:

To assess proteins as building components for bioelectronic devices.
To compare protein conduction with saturated and conjugated molecules.
To investigate mechanisms enabling efficient protein conduction.

Main Methods:

Compilation and analysis of nanometer-scale and macroscopic electronic transport measurements.
Evaluation of measurements across various organic molecules and proteins.
Consideration of the influence of measurement methods on results.

Main Results:

Proteins conduct better than saturated molecules and slightly poorer than conjugated molecules.
Cofactors (redox-active or conjugated) enhance protein conduction.
Natural electron transfer proteins do not show an obvious conduction advantage.

Conclusions:

Proteins are viable candidates for bioelectronic devices.
Conduction mechanisms likely involve hopping at higher temperatures and tunneling at lower temperatures.
Protein conduction is influenced by molecular structure and cofactors.