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Electric field regulated signaling pathways.

Qian Liu1, Bing Song1

  • 1Cardiff Institute of Tissue Engineering & Repair, School of Dentistry, College of Biomedical & Life Sciences, Cardiff University, Cardiff, CF14 4XY, United Kingdom.

The International Journal of Biochemistry & Cell Biology
|September 27, 2014
PubMed
Summary
This summary is machine-generated.

Physiological electric fields (EF) guide cell development and disease. This review details how EFs trigger cell migration and proliferation via unique signaling networks involving ion channels and receptors.

Keywords:
AChR and NMDAREGFRElectric fieldElectrotaxisMAPKPI3K/AktPTEN

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Area of Science:

  • Cellular biology
  • Biophysics
  • Physiology

Background:

  • Physiological electric fields (EF) act as crucial guidance cues in biological systems.
  • Cellular responses like migration and proliferation are influenced by EFs in development and disease.
  • Existing knowledge on signaling pathways for chemical gradients differs from those activated by electrical stimulation.

Purpose of the Study:

  • To review cellular responses to physiological electric fields.
  • To summarize the primary signaling networks activated by EF-induced cellular responses.

Main Methods:

  • Literature review of studies on cellular responses to electric fields.
  • Analysis of signaling pathways involved in EF-induced cell migration and proliferation.
  • Synthesis of information on ion channels, membrane receptors, and intracellular pathways.

Main Results:

  • EFs induce significant cellular responses, including migration and proliferation.
  • EF-induced signaling involves a unique network distinct from chemical gradient responses.
  • Key components include regulation of ion channels, membrane receptors, and associated intracellular pathways.

Conclusions:

  • Electric fields are potent regulators of cellular behavior.
  • Understanding EF-induced signaling networks is vital for physiological and pathological contexts.
  • This review consolidates current knowledge on the unique signaling mechanisms activated by electric fields.