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Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
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Delivering a disease-modifying treatment for Huntington's disease

Bruno M D C Godinho1, Meenakshi Malhotra2, Caitriona M O'Driscoll2

  • 1Pharmacodelivery Group, School of Pharmacy, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland.

Drug Discovery Today
|September 27, 2014
PubMed
Summary

Huntington's disease (HD) treatments focus on gene-silencing strategies like RNA interference and antisense oligonucleotides to target the toxic mutant Huntingtin gene, showing promise in preclinical studies.

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