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Default mode network subsystem alterations in obsessive-compulsive disorder.

Jan C Beucke1, Jorge Sepulcre1, Mark C Eldaief1

  • 1Jan C. Beucke, MS, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany and Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA; Jorge Sepulcre, MD, PhD, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston and Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts, USA; Mark C. Eldaief, MD, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Miriam Sebold, MS, Department of Psychology, Humboldt-Universität zu Berlin and Emotional Neuroscience Group, Charité Universitätsmedizin Berlin, Berlin, Germany; Norbert Kathmann, PhD, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany; Christian Kaufmann, MS, Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.

The British Journal of Psychiatry : the Journal of Mental Science
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Summary
This summary is machine-generated.

Obsessive-compulsive disorder (OCD) is linked to altered brain connectivity. This study found reduced self-referential processing in the default mode network in OCD patients, suggesting new therapeutic targets.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Brain Imaging

Background:

  • Traditional neurobiological models of obsessive-compulsive disorder (OCD) focus on corticostriatal regions.
  • Research into default mode network (DMN) integrity in OCD has yielded inconsistent findings.
  • This study aims to clarify DMN abnormalities in OCD.

Purpose of the Study:

  • To investigate the integrity of DMN subsystems in individuals with OCD.
  • To resolve conflicting results regarding DMN function in OCD.
  • To identify specific neural correlates of self-referential processing in OCD.

Main Methods:

  • Used seed-based resting-state functional connectivity analysis.
  • Compared 11 DMN components in 46 OCD patients and 46 healthy controls.
  • Employed functional magnetic resonance imaging (fMRI).

Main Results:

  • Observed significantly reduced connectivity within the dorsal medial prefrontal cortex self subsystem in the OCD group.
  • This finding persisted after controlling for medication and affective disorder history.
  • Found increased connectivity between the self subsystem and salience and attention networks in OCD patients.

Conclusions:

  • Individuals with OCD exhibit abnormalities in a neural system crucial for self-referential processing.
  • These findings highlight the role of the DMN self subsystem in OCD.
  • Further research should explore dynamic interactions between the DMN self subsystem and other large-scale brain networks in OCD.