Tetrad analysis in the mouse
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Mouse Genome Engineering Using Designer Nucleases
Published on: April 2, 2014
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Danny E Miller1, R Scott Hawley1
1Stowers Institute for Medical Research, Kansas City, Missouri, USA, and the Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, USA.
Nature Genetics
|September 27, 2014
Abstract:
Meiotic tetrad analysis is a powerful tool for analyzing all four products of a single meiosis. A new method for tetrad analysis in mammals provides valuable insights into the mechanisms that mediate the exchange of DNA sequences between homologs during meiosis and their influence on the evolution of recombination hotspots.
