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Updated: Apr 23, 2026
Diffusion Imaging in the Rat Cervical Spinal Cord
Published on: April 7, 2015
Structural imaging of the cervical spinal cord with suppressed CSF signal using DANTE pulse trains
Linqing Li1, Yazhuo Kong1, Yuri Zaitsu1
1FMRIB Centre, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Purpose:
We propose DANTE (Delays Alternating with Nutation for Tailored Excitation) moving fluid attenuation preparation pulse trains, in conjunction with T1 , T2 , and proton-density-weighted fast spin-echo (T1w-TSE, T2w-TSE and PDw-TSE) imaging readout, and three-dimensional fast low flip angle shots (3D-FLASH) T1 -weighted imaging readout to achieve CSF-suppressed high-spatial resolution multicontrast cervical spinal cord images.
Methods:
DANTE pulse trains, consisting of a rapid series of low flip angle radiofrequency pulses interspersed with gradients, were used to substantially attenuate the longitudinal magnetization of flowing spins relative to static tissue/fluid, whose longitudinal magnetization is mostly preserved. We hypothesized that the contrast between spinal cord and cerebrospinal fluid (CSF) could be maximized due to moving CSF signal suppression.
Results:
We demonstrate that metrics of contrast-to-noise ratio between spinal cord, nerve root, and CSF regions (CNRcord-CSF and CNRnerve-CSF ) are improved by at least a factor of 2 when compared with images acquired with non-prepared approaches and with 2D multiple-echo data image combination (MEDIC) imaging. In addition, we find that sagittal image quality can be significantly improved due to flow suppression effects from the DANTE preparation pluses.
Conclusion:
DANTE prepared imaging techniques for moving CSF signal attenuation are promising tools for cervical spinal cord imaging.
