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Peroxisomes are specialized organelles present in fungi, plant, and animal cells. It can vary in number, size, morphology, and activity depending on the type of tissue and the nutritional state of the cell. For example, cells with active lipid metabolism, such as adipocytes, neurons, and hepatocytes, have more peroxisomes than other cells in the body. Besides their primary role in breaking down complex organic molecules, peroxisomes can also synthesize specific macromolecules and participate in...

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Updated: Apr 23, 2026

Dissection and Lipid Droplet Staining of Oenocytes in Drosophila Larvae

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Published on: December 28, 2019

Five new oxylipins from Chaenomeles sinensis.

Chung Sub Kim¹, Oh Wook Kwon, Sun Yeou Kim

¹Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, 300 Chonchon-dong, Jangan-ku, Suwon, 440-746, Republic of Korea.

|September 27, 2014

Summary

Researchers discovered five new oxylipins, chaenomic acid A-E, from Chaenomeles sinensis twigs. These compounds, along with known ones, were evaluated for their potential to inhibit nitric oxide production and exhibit anticancer properties.

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Area of Science:

Natural Product Chemistry
Medicinal Plant Research
Pharmacology

Background:

Korean medicinal plants are a rich source of bioactive compounds.
Chaenomeles sinensis twigs have not been extensively studied for their chemical constituents.

Purpose of the Study:

To isolate and characterize new oxylipins from Chaenomeles sinensis.
To evaluate the biological activities of isolated compounds, including anti-inflammatory and cytotoxic effects.

Main Methods:

Structure elucidation using comprehensive spectroscopic techniques (1D/2D NMR, LC/MS).
Isolation of compounds via spectroscopic methods and olefin cross-metathesis.
In vitro assays for nitric oxide inhibition and cytotoxicity against human cancer cell lines.

Main Results:

Five new oxylipins, designated chaenomic acid A-E, were identified.
Six known oxylipins were also isolated and characterized.
The isolated compounds were screened for their inhibitory effects on nitric oxide production and cytotoxic activities.

Conclusions:

Chaenomeles sinensis is a source of novel oxylipins with potential biological activities.
Further investigation into these compounds may lead to the development of new therapeutic agents.