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Updated: Apr 23, 2026

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Did you write a protocol before starting your project?

Ko Bando1, Tosiya Sato

  • 1Department of Cardiac Surgery, The Jikei University School of Medicine, 3-25-8, Nishi Shinbashi, Minato-Ku, Tokyo, 105-8461, Japan, kobando@jikei.ac.jp.

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Summary
This summary is machine-generated.

Writing clinical papers effectively requires careful planning. This review emphasizes creating a protocol first to improve manuscript quality and increase acceptance in top-tier journals.

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Area of Science:

  • Clinical research methodology
  • Scientific manuscript preparation

Background:

  • Many clinical research projects fail to yield impactful publications.
  • Authors often struggle with both project execution and manuscript writing.

Purpose of the Study:

  • To highlight the importance of a protocol in clinical research.
  • To provide a roadmap for authors to publish in high-impact journals.

Main Methods:

  • Review of best practices in clinical study design and manuscript preparation.
  • Guidance on protocol development and its role in publication success.

Main Results:

  • A well-defined protocol is crucial for successful clinical research.
  • Systematic manuscript preparation enhances the likelihood of journal acceptance.

Conclusions:

  • Initiating clinical projects with a protocol is essential.
  • Adhering to structured writing steps improves publication outcomes in reputable journals.