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Time trends in gastroparesis treatment
Anwar Dudekula1, Shiraz Rahim, Klaus Bielefeldt
1Division of Gastroenterology, University of Pittsburgh Medical Center, 200 Lothrop St, Pittsburgh, PA, 15213, USA.
Digestive Diseases and Sciences
|September 27, 2014
Summary
Gastroparesis management shifted from prokinetics to symptom relief and mood disorder treatment. This study observed a significant decrease in prokinetic use and an increase in antiemetics, opioids, and antidepressants.
Area of Science:
- Gastroenterology
- Clinical Medicine
- Pharmacology
Background:
- Delayed gastric emptying defines gastroparesis, but prokinetics offer limited symptom relief and carry risks.
- This study examines how new information and regulatory changes impacted gastroparesis management.
Purpose of the Study:
- To analyze trends in gastroparesis management.
- To evaluate changes in medication use for gastroparesis patients between 2003 and 2012.
Main Methods:
- Retrieved electronic medical records of 709 patients diagnosed with gastroparesis between 2003 and 2012.
- Abstracted demographic, clinical, and survival data.
Main Results:
- Prokinetic use decreased from 81% to 43%, while antiemetic use rose from 14% to 41%.
- Prescription of opioids and antidepressants significantly increased.
- Diabetes and idiopathic causes were most common; mortality was linked to age, comorbidity, anxiety, and medication use.
Conclusions:
- Gastroparesis treatment trends are shifting away from prokinetics.
- Current management focuses more on symptom-oriented therapy and addressing mood disorders.
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